Saint Bernard refers primarily to Bernard of Clairvaux (1090–1153), a Christian saint, mystic, and reformer of the Cistercian order.
Another prominent meaning is St. Bernard (dog), a breed of dog.
St. Bernard, St Bernard or San Bernard may also refer to:
- Bernard degli Uberti (d. 1133), Catholic saint, Italian abbot, bishop, papal legate, and cardinal
- Bernard of Corleone (1605–1667), Sicilian friar, Franciscan Blessed
- Bernard of Menthon (c. 1020–1081 or 1086), Catholic saint, Frankish founder of the hostel at Great St Bernard Pass, and namesake of the famous dog breed
- Bernard of Thiron (1046–1117), Catholic saint, French founder of the Tironensian Order
- Bernardo Tolomei (1272–1348), Catholic saint, Italian theologian and founder of the Olivetans
- Bernard of Vienne (778–842), Catholic saint, French bishop of Vienne 810–842.
- São Bernardo do Campo, São Paulo, municipality in the Metropolitan Region of São Paulo
- São Bernardo, Maranhão, municipality in the Northeast region of Brazil
- Saint-Bernard-de-Lacolle, Quebec, municipality in Montérégie region
- Saint-Bernard, Quebec, municipality in Chaudière-Appalaches region
- Saint-Bernard-de-Michaudville, Quebec, municipality in Les Maskoutains Regional County Municipality, Montérégie region
- Saint-Bernard-sur-Mer, community in the municipality of L'Isle-aux-Coudres, Quebec
- St. Bernard, Nova Scotia, community in the District of Clare, Digby County
- Saint-Bernard, Ain, commune in Auvergne-Rhône-Alpes region
- Saint-Bernard, Côte-d'Or, commune in Bourgogne-Franche-Comté region
- Saint-Bernard, Haut-Rhin, commune in Alsace, Grand Est region
- Saint-Bernard, Isère, commune in Auvergne-Rhône-Alpes region
- Saint Bernard, Southern Leyte, fourth-class municipality, Eastern Visayas region
- (Col du) Grand Saint-Bernard, French name for Great St Bernard Pass, road pass in south-western Switzerland, to Italy
- Great St Bernard Tunnel, tunnel circumventing Great St Bernard Pass
- English for San Bernardino Pass, a Swiss Alpine pass connecting Thusis (Graubünden) and Bellinzona (Ticino) in south-eastern Switzerland.
- St. Bernard, Ohio, village in Hamilton County
- St. Bernard Parish, Louisiana, in the New Orleans–Metairie–Kenner Metropolitan Statistical Area
- Saint Bernard, Louisiana, unincorporated community in St. Bernard Parish
- Saint Bernard, Nebraska, unincorporated community in Platte County
- St. Bernard Township, Platte County, Nebraska, township in Platte County
- San Bernard River, in Texas
- San Bernard National Wildlife Refuge, wildlife conservation area along the Texas coast
- St. Bernard, a brand formerly used by Dunnes Stores
- Texan schooner San Bernard, two-masted ship of the Second Texas Navy