Subber grew up in New York City, where both of his parents were theatre ticket brokers. He attended New York University. He was an assistant stage manager for the revue Hellzapoppin' starring Olsen and Johnson and assistant to producer John Murray Anderson for Billy Rose's Aquacade at the 1939 New York World's Fair.
Subber won a Tony Award as producer of the musical Kiss Me, Kate, which ran on Broadway from 1948 to 1951. Subber has often been described as conceiving of the show while working as a stagehand on a production of The Taming of the Shrew starring the real-life husband and wife Alfred Lunt and Lynn Fontanne and noticing that the couple "quarreled almost as much off stage as they did in the play". (However, a representative of the estate of Samuel and Bella Spewack, who wrote the musical's book, has stated that the backstage conflict plot came purely from the Spewacks' imagination and was not inspired by Lunt and Fontanne's relationship.) However, Subber maintained that his role as the stage manager for Lunt and Fontaine inspired the idea, and he wrote the original book at the insistence of his lifelong friend, Montgomery Clift, who locked him in a hotel room until the work was completed. Book in hand, Clift then introduced Subber to Cole Porter who wrote the music for "Kiss Me Kate" in 10 days.
Subber also received Tony nominations for Best Play as producer of both William Inge's The Dark at the Top of the Stairs and Paddy Chayefsky's The Tenth Man, each of which also ran for more than a year on Broadway. He eventually became associated with Neil Simon and produced seven of his plays on Broadway: Barefoot in the Park, The Odd Couple, The Star-Spangled Girl, Plaza Suite, Last of the Red Hot Lovers, The Gingerbread Lady, and The Prisoner of Second Avenue. Of these seven plays, five resulted in Tony nominations for Subber as producer of a Best Play nominee (Barefoot in the Park, The Odd Couple, Plaza Suite, Last of the Red Hot Lovers, and The Prisoner of Second Avenue), and Barefoot in the Park also earned Subber a nomination as Best Producer (Dramatic).
After Subber's run of Neil Simon plays ended, he produced two more musicals on Broadway: Gigi by Alan Jay Lerner and Frederick Loewe in 1973, and 1600 Pennsylvania Avenue by Lerner and Leonard Bernstein in 1976. Regarding the latter show, Subber said in a 1980 interview, "I loathed it. It wasn't working out well. I tried desperately to get everyone to abandon it. After many fights, I left the production." Subber moved to Mendocino, California. His next return to New York was to sign contracts for his last production, Patrick Meyers' play K2, which was originally scheduled to run on Broadway in 1981 but finally arrived on Broadway in 1983.
- Jones, Welton (1984-01-15). "A Broadway legend with a loving link to `Kate': O'Brien's new book stirs Saint-Subber". San Diego Union. p. E1.
- Barron, Mark (1949-01-10). "Ex-Office Boy with 50 Friends with $7,000 Hits the Jackpot". The Milwaukee Journal. Associated Press. p. 1, § Green Sheet.
- Holden, Stephen (1994-04-21). "Saint Subber, Theater Producer and a Neil Simon Partner, 76". The New York Times.
- "Broadway Impresario Arnold Saint-Subber, 76". Chicago Tribune. New York Times News Service. 1994-04-24. p. 6, § Chicagoland.
- Green, Stanley (1976). Encyclopedia of the Musical Theatre. Da Capo. p. 237. ISBN 0-306-80113-2. Retrieved 2010-05-23.
- Brown, Jared (2005). The Fabulous Lunts. Bloomington, Ind.: AuthorHouse. p. 256. ISBN 1-4208-5470-4. Retrieved 2010-05-23.
- Kowinski, William (2007-06-07). "Prime Cole Porter". North Coast Journal. Retrieved 2010-05-23.
- Kenneth Jones (1999-10-08). "So in Love: Kiss Me, Kate Company Meets the Press in Open Rehearsal". Playbill.com. Archived from the original on 2012-10-15. Retrieved 2010-05-23.
- Saint Subber at the Internet Broadway Database
- "Archived copy". Archived from the original on 2010-01-13. Retrieved 2010-05-24.
- Lawson, Carol (1980-10-03). "Saint Subber coming back with Himalayas play starring Sheen". The New York Times. p. C2.
- Of the six shows Subber produced on Broadway during the 1967-68 season, Dr. Cook's Garden and Carry Me Back to Morningside Heights credited him as "Saint Subber", while There's a Girl in My Soup, Weekend, The Little Foxes, and Plaza Suite credited him as "Saint-Subber". Goldman, William (1969). The Season: A Candid Look at Broadway. New York: Limelight Editions. pp. 22, 54, 154, 262, 316. ISBN 0-87910-023-0.
- Goldman, William (1969). The Season: A Candid Look at Broadway. New York: Limelight Editions. p. 24. ISBN 0-87910-023-0.
- Merryman, Richard (1971-05-07). "When the Funniest Writer in America Tried to Be Serious". Life. p. 75.