The Sale River is a river in the Kimberley of the Australianstate of Western Australia. The river was discovered and named on 9 June 1865 by an expedition from the short-lived Camden Harbor settlement (in Camden Sound) searching for pastoral land. The expedition comprised Treverton Charles Sholl, Alexander Joseph McRae, PC W. Gee, John Stainer and native constable Billy.
The headwaters of the river rise near Spong Pyramid at the southern edge of the Elizabeth and Catherine Range and flow in a westerly direction before discharging into Doubtful Bay near Storr Island. The only tributary to the Sale is the Berckelman River.
The mouth of the Sale River at Doubtful Bay has a depth of about 30 metres (98 ft) but the mouth itself is blocked by a rock bar at low tide. Cruise boats regularly enter the river from the bay and many anchorages exist along the length of the river with gorges and sandy beaches that are popular with tourists.