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CAS Number
PubChem CID
ECHA InfoCard 100.237.268 Edit this at Wikidata
Chemical and physical data
Formula C21H17Cl3N4OS
Molar mass 479.81 g/mol[1][2]
3D model (JSmol)
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Salubrinal is a drug which acts as a specific inhibitor of eIF2α phosphatase enzymes[3][4][5] and is primarily used experimentally, to study stress responses in eukaryotic cells associated with the action of eIF2. Salubrinal indirectly inhibits eIF2 as a result of reduced dephosphorylation of its α-subunit,[6] resulting in activation of stress response pathways usually triggered by events such as oxidative stress or buildup of unfolded protein in the endoplasmic reticulum.[7] Salubrinal has putative therapeutic value due to its function,[3][5] but is as yet only used experimentally. Salubrinal is being studied at Indiana University for its potential to fight osteoporosis and accelerate bone healing.[8]


  1. ^ "SALUBRINAL | 405060-95-9". ChemicalBook. Retrieved 2010-10-05. 
  2. ^ "Salubrinal: sc-202332" (PDF). Santa Cruz Biotechnology, Inc. 2010-07-28. Retrieved 2010-10-05. 
  3. ^ a b Lewerenz, Jan; Maher, Pamela (2009-01-09). "Basal Levels of eIF2α Phosphorylation Determine Cellular Antioxidant Status by Regulating ATF4 and xCT Expression". The Journal of Biological Chemistry. The American Society for Biochemistry and Molecular Biology, Inc. 284 (2): 1106. doi:10.1074/jbc.M807325200. PMC 2613630Freely accessible. 
  4. ^ Kessel, David (2006-08-11). "Protection of Bcl-2 by sulubrinal". Biochemical and Biophysical Research Communications. Elsevier Inc. 346 (4): 1320–3. doi:10.1016/j.bbrc.2006.06.056. PMC 2978664Freely accessible. PMID 16806073. Retrieved 2010-10-05. 
  5. ^ a b Boyce M; Bryant KF; Jousse C; Long K; Harding HP; Scheuner D; Kaufman RJ; Ma D; Coen DM; Ron D; Yuan J (February 2005). "A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress". Science. 307 (5711): 935–9. doi:10.1126/science.1101902. PMID 15705855. Retrieved 2010-10-05. 
  6. ^ "Entrez Gene: EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa". National Center for Biotechnology Information, U.S. National Library of Medicine. Retrieved 2010-10-05. 
  7. ^ Wek R, Jiang H, Anthony T (February 2006). "Coping with stress: eIF2 kinases and translational control" (PDF). Biochemical Society Transactions. Biochemical Society. 34 (1): 7–11. doi:10.1042/BST20060007. PMID 16246168. Retrieved 2010-10-05. 
  8. ^ "New compound may accelerate bone healing, prevent osteoporosis". August 2011. Retrieved 2011-08-29.