Sancho Lyttle was born to Evelyn Little and Burt Cain. Members of her family spell their surname 'Lyttle' or 'Little'. Sancho has a younger brother, Xavier Little. Sancho attended St. Vincent Girls' High School where she played net ball and ran various Track and Field events. She never played basketball until prompted to do so after her move to the United States. She and three other girls from her country were requested by her Junior College and current assistant coach for the University of Houston Women's team Wade Scott who offered to teach them how to play the game of basketball.
Sancho Lyttle played collegiate basketball at Clarendon College before transferring to the University of Houston from 2003–2005 where she currently holds the record for single season rebound average (2004–2005), offensive rebounds (04-05) and most rebounds in a single season (04-05). She also holds the career record for highest rebounding average.
She is currently a power forward in the WNBA for the Atlanta Dream. Through her career, she has scored 1,505 points, collected 1,041 rebounds, and has 200 assists, 242 steals, and 96 blocks through six seasons. She was the fifth overall draft pick in the 2005 WNBA Draft, out of Houston.
In 2010 she had career highs in points and rebounds with 27 and 20, respectively.