Brondello started her WNBA career in 1998 by being selected in the fourth round (34th overall) by the newly formed Detroit Shock, becoming an All-Star in the first WNBA All-Star Game in 1999. She was selected by the Indiana Fever in late 1999's expansion draft, but never played a game for them, being traded to the Miami Sol along with a first-round pick for Stephanie McCarty. After sitting out of the 2002 season due to a foot injury playing for Wuppertal during the WNBA offseason, Brondello signed as a free agent with the Seattle Storm in 2003, joining fellow Australians Lauren Jackson and Tully Bevilaqua. Brondello was one of the top three-point shooters in league history, her .410 percentage ranking fourth all-time.
On the Australian National Team, Brondello joined the team before the age of 18 and remained on the Opals for 17 years, and her 302 games made Brondello the third most capped Australian player, behind Robyn Maher and Karen Dalton. Brondello's tournaments with Australia include four World Championships, with two bronze medals, and four Olympic tournaments, with two silver medals and a bronze. Twice she sat out of the WNBA due to Olympic commitments, in 2000 and 2004. The 2004 tournament in Athens turned out to be Brondello's last major event, with her afterwards investing in a coaching career.
In 2009 Brondello was inducted into the Queensland Sport Hall of Fame.
Brondello and her husband, associate head coach Olaf Lange, were fired by the Silver Stars in September 2010. Brondello finished her only season as head coach with a 14–20 record, third best in the Western Conference. They were eliminated in the first round of the playoffs by Phoenix two games to none. General manager Dan Hughes regained the title of head coach in January 2011, returning to the dual role he held before promoting Brondello.  Brondello would become an assistant coach for the Los Angeles Sparks for the 2011 season.