Cane's father is African American and her mother is Italian, a native of Viggiù. After her parents' divorce in 1971, Cane moved to her mother's hometown. Holding a degree in foreign languages, she started to work in tourism sector and became the director of a hotel. She is also well-versed in the local Western Lombard dialect (dialetto bosino).
Cane became Lega Nord's candidate for Viggiù mayor in June 2009 elections. She was elected the first female non-white mayor of Italy after winning about 30% of the votes. In an interview with The Independent, she told that she is an Obama voter.