Sanjiv Sam Gambhir
|Sanjiv Sam Gambhir|
November 23, 1962 |
|Fields||Nuclear Medicine, Radiology, and Bioengineering|
|Alma mater||University of California, Los Angeles|
|Academic advisors||M.E. Phelps, S.C. Huang, and H.R. Herschman|
|Known for||Molecular Imaging, Nuclear Medicine, PET-CT, and Early Cancer Detection|
|Notable awards||Institute of Medicine (IOM) of the US National Academies (2008)|
Sanjiv Sam Gambhir, MD, PhD (born November 23, 1962) is an American physician-scientist. He is the Virginia and D.K. Ludwig Professor in Cancer Research, Chairman of the Department of Radiology at Stanford University School of Medicine, and a professor by courtesy in the departments of Bioengineering and Materials Science and Engineering at Stanford University. Additionally, he serves as the Director of the Molecular Imaging Program at Stanford (MIPS) and Canary Center at Stanford for Cancer Early Detection. To date, he serves on many editorial and advisory boards and committees. He serves as the PI to various extramural funds as well as private foundations funds.
Gambhir was born in Ambala, India and moved to the US with his parents and sister in 1969. He was raised in Phoenix, Arizona. He is married to Aruna Bodapati Gambhir and lives in the Bay Area. He is an American citizen.
Education and employment
Gambhir is a Phi Beta Kappa graduate of Arizona State University where he received his B.S. in Physics. He then entered the combined M.D-Ph.D. Medical Scientist Training Program (MSTP) at the University of California Los Angeles and received his MD and PhD in biomathematics. He received the highest honor given to a UCLA graduate student, the outstanding graduate student award gold medal award in 1990.
His first academic appointment was in 1994 at UCLA as an Assistant Professor of Molecular & Medical Pharmacology. He was a Clinical Attending in the Nuclear Medicine Department at Center for Health Sciences at UCLA starting in 1997. He was appointed tenure Professorship at UCLA in 2003. In 2003, he moved to Stanford University and was appointed Professor of Radiology, Head of Nuclear Medicine, Director of Molecular Imaging Program at Stanford (MIPS), and Member of the Bio-X Program. He became the Virginia and D.K. Ludwig Professor for Clinical Investigation in Cancer Research, which is an Endowed Professorship in 2009. He was appointed the Chair of Radiology in August 2011.
Honors and awards
Gambhir has many honors and awards. In the last decade he has received the following: Taplin Award, Holst Medal, Academy of Molecular Imaging (AMI) Distinguished Basic Scientist of the Year Award, Society for Molecular Imaging (SMI) Achievement Award, Distinguished Clinical Scientist Award from Doris Duke Charitable Foundation, Hounsfield Medal (Imperial College London), fellowship of the American Institute for Medical and Biological Engineering (AIMBE), Paul C. Aebersold Award, Organizer and Co-Chair for the Nobel Symposium in Imaging (2008), Inducted as a member of the American Society of Clinical Investigator (ASCI), Tesla Medal, Elected to the Institute of Medicine (IOM) of the US National Academies, Parmley Prize, Radiological Society of North American (RNSA) Outstanding Researcher Award, The Gopal Subramanian Lifetime Achievement Award, the George Charles de Hevesy Nuclear Pioneer Award, Aunt Minnie Award, Distinguished Scientist Award for Distinguished Contributions to Nuclear Medicine, Society of Asian American Scientists in Cancer Research Award, the American Association of Indian Scientists in Cancer Research Lifetime Achievement Award, the American Association for the Advancement of Science (AAAS) Fellow Award. and J. Allyn Taylor International Prize in Medicine.
His research focuses on imaging assays to monitor fundamental cellular/molecular events in living subjects with an emphasis on cancer. Technologies being utilized include micro-positron emission tomography (microPET), bioluminescence imaging, fluorescence optical imaging, Raman optical imaging, ultrasound, and photoacoustics in small animal models. Particular interest of his research and lab is early cancer detection including combining in vivo and in vitro diagnostics.
Clinical applications in humans include the use of PET-CT with novel tracers and translational trials with new imaging modalities (e.g., Raman and Photoacoustics), strategies for early cancer detection.
Decision Management Models for the use of FDG PET in cancer, PET reporter gene technology, multimodality reporter genes, imaging of gene/cell therapies, imaging of intracellular events in living subjects (e.g., protein-protein interactions), bioluminescence resonance energy transfer (BRET) in living subjects, nanoparticle based imaging, Raman imaging in vivo and photoacoustic imaging with novel imaging agents.
Gambhir has published over 549 publications in peer reviewed journals, has authored and co-authored several textbooks and holds 41 patents that are issued or filed.
- Witney T.H.; James M.L.; Shen B.; Chang E.; Pohling C.; Arksey N.; Hoehne A.; Shuhendler A.; Park J.H.; Bodapati D.; Weber J.; Gowrishankar G.; Rao J.; Chin F.T.; Gambhir S.S. (Oct 2015). "PET Imaging of Tumor Glycolysis Downstream of Hexokinase Through Noninvasive Measurement of Pyruvate Kinase M2" (PDF). Science Translational Medicine. 7 (310): 310. doi:10.1126/scitranslmed.aac6117. PMID 26491079.
- Ronald J.A.; Chuang H.Y.; Dragulescu-Andrasi A.; Hori S.S.; Gambhir S.S. "Detecting Cancers Through Tumor-Activatable Minicircles That Lead to a Detectable Blood Biomarker" (PDF). PNAS USA. 112 (10): 3068–73. doi:10.1073/pnas.1414156112.
- Pan Y.; Volkmer J.P.; Mach K.E.; Rouse R.V.; Sahoo D.; Chang T.C.; Metzner T.J.; de Rijn M.; Skinner E.C; Gambhir S.S.; Weissman I.L.; Liao J.C. (2014). "Endoscopic Molecular Imaging of Human Bladder Cancer Using a CD47 Antibody". Science Translational Medicine. 6 (260): 260. doi:10.1126/scitranslmed.3009457. PMID 25355698.
- Smith, B.R.; E.E.B Ghosn; H. Rallapalli; J.A. Prescher; T. Larson; L.A. Herzenberg; S.S. Gambhir (2014). "Selective uptake of single-walled carbon nanotubes by circulating monocytes for enhanced tumor delivery." (PDF). Nature Nanotechnology. 9: 481–487. doi:10.1038/nnano.2014.62.
- Pu, K.; A.J. Shuhendler; J.V. Jokerst; J. Mei; S.S. Gambhir; Z. Bao; J. Rao (2014). "Semiconducting Polymer Nanoparticles as Photoacoustic Molecular Imaging Probes in Living Mice." (PDF). Nature Nanotechnology. 9 (3): 233–9. doi:10.1038/nnano.2013.302. PMID 24463363.
- Bohndiek, S.E.; A. Wagadarikar; C.L. Zavaleta; D. Van de Sompel; E. Garai; J.V. Jokerst; S. Yazdanfar; S.S. Gambhir (2013). "A Small Animal Raman Instrument for Rapid, Wide-Area, Spectroscopic Imaging." (PDF). PNAS USA. 110 (30): 12408–13. doi:10.1073/pnas.1301379110. PMC . PMID 23821752.
- Zavaleta, C.; E. Garai; J.T. Liu; S. Sensam; M.J. Mandella; D. Van de Sompel; S. Friedland; J. Van Dam; C.H. Contag; S.S. Gambhir (2013). "A Raman-Based Endoscopic Strategy for Multiplexed Molecular Imaging." (PDF). PNAS USA. 110 (25): E2288–97. doi:10.1073/pnas.1211309110. PMC . PMID 23703909.
- Jokerst, J.; C. Khademi; S.S. Gambhir (2013). "Intracellular Aggregation of Multimodal Silica Nanoparticles for Ultrasound-Guided Stem Cell Implantation.". Science Translational Medicine. 5 (177): 177ra35. doi:10.1126/scitranslmed.3005228. PMC . PMID 23515077.
- Ziv, K.; S.S. Gambhir (2013). "Bioengineering and Regenerative Medicine: Keeping Track." (PDF). Nature Materials. 12 (3): 180–1. doi:10.1038/nmat3579. PMID 23422714.
- Chan, C.T.; R.E. Reeves; R. Geller; S.S. Yaghoubi; A. Hoehne; D.E. Solow-Cordero; G. Chiosis; T.F. Massoud; R. Paulmurugan; S.S. Gambhir (2012). "Discovery and Validation of Small-Molecule Heat-Shock Protein 90 Inhibitors Through Multimodality Molecular Imaging in Living Subjects." (PDF). PNAS USA. 109 (37): E2476–85. doi:10.1073/pnas.1205459109. PMC . PMID 22895790.
- Kircher, M.F.; A. de la Zerda; J.V. Jokerst; C.L. Zavaleta; P.J. Kempson; E. Mittra; R. Huang; C. Campos; F. Habte; R. Sinclair; C.W. Brennan; I.K. Mellinghoff; E.C. Holland; S.S. Gambhir (April 2012). "A Brain Tumor Molecular Imaging Strategy Using a New Triple-Modality MRI-Photoacoustic-Raman Nanoparticle.". Nature Medicine. 18 (5): 829–34. doi:10.1038/nm.2721. PMC . PMID 22504484.
- Hori, S.S.; S.S. Gambhir (November 2011). "Mathematical Model Identifies Blood Biomarker-Based Early Cancer Detection Strategies and Limitations." (PDF). Science Translational Medicine. 3 (109): 109ra116. doi:10.1126/scitranslmed.3003110. PMC . PMID 22089452.
- Thakor, A.; R. Luong; R. Paulmurugan; F. Lin; P. Kempen; C. Zavaleta; P. Chu; T.F. Massoud; R. Sinclair; S.S. Gambhir (April 2011). "The Fate and Toxicity of Raman-Active Silica-Gold Nanoparticles in Mice. (Cover Article)" (PDF). Science Translational Medicine. 3 (79): 79ra33. doi:10.1126/scitranslmed.3001963. PMC . PMID 21508310.
- Dragulescu-Andrasi, A.; C.T. Chan; A. De; T.F. Massoud; S.S. Gambhir (July 2011). "Bioluminescence Resonance Energy Transfer (BRET) Imaging of Protein-Protein Interactions within Deep Tissues of Living Subjects." (PDF). PNAS. 108 (20): 12060–5. doi:10.1073/pnas.1100923108. PMC . PMID 21730157.
- Gaster, R.; D. Hall; C. Nielsen; S. Osterfeld; H. Yu; K. Mach; R. Wilson; B. Murmann; J. Liao; S.S. Gambhir; S. Wang (August 2010). "Matrix-insensitive Protein Assays Push the Limits of Biosensors in Medicine." (PDF). Nature Medicine. 15 (11): 1327–32. doi:10.1038/nm.2032. PMID 19820717.
- Liu, H. Patel, M.R., Prescher, J.A., Patsialou, A., Qian, D., Lin, J., Wen, S., Chang, Y.F., Bachmann, M.H., Shimono, Y., Dalerba, P., Adorno, M., Lobo, N., Bueno, J., Dirbas, F.M., Goswami, S., Somio, G., Condeelis*, J., Contag*, C.H., Gambhir*, S.S., Clarke*, M.F. Cancer Stem Cells from Human Breast Tumors are Involved in Spontaneous Metastases in Orthotopic Mouse Models. Proceedings of the National Academy of Sciences (USA), 107(42): 18115-20, 2010. (*Co-Corresponding Authors) PMCID: PMC2964232
- Fan-Minogue, H.; Z. Cao; R. Paulmurugan; C.T. Chan; T.F. Massoud; D.W. Felsher; S.S. Gambhir (September 2010). "Noninvasive Molecular Imaging of c-Myc Activation in Living Mice." (PDF). PNAS. 107 (36): 15892–7. doi:10.1073/pnas.1007443107. PMC . PMID 20713710.
- Massoud, T.; R. Paulmurugan; S.S. Gambhir (August 2010). "A Molecularly Engineered Split Reporter for Imaging Protein Protein Interactions with Positron Emission Tomography." (PDF). Nature Medicine. 16 (8): 921–6. doi:10.1038/nm.2185. PMC . PMID 20639890.
- Loening, A. Dragulescu-Andrasi, S.S. Gambhir. (2010). "A Red-Shifted Renilla Luciferase for Transient Reporter-Gene Expression.". Nature Methods. 7 (1): 5–6. doi:10.1038/nmeth0110-05. PMID 20038949.
- Zavaleta, C.; B. Smith; I. Wilton; W. Doering; G. Davis; B. Shojaei; M. Natan; S.S. Gambhir (August 2009). "Multiplexed imaging of surface enhanced Raman scattering nanotags in living mice using noninvasive Raman spectroscopy." (PDF). PNAS. 106 (32): 13511–6. doi:10.1073/pnas.0813327106. PMC . PMID 19666578.
- Yaghoubi, S.; M. Jensen; N. Sastyamurthy; S. Pubhiraja; D. Paid; J. Czernin; S.S. Gambhir (January 2009). "Non-invasive Detection of Therapeutic Cytolytic T-Cells with [18F]-FHBG PET in a Patient with Glioma." (PDF). Nature Clinical Practice Oncology. 6 (1): 53–8. doi:10.1038/ncponc1278. PMC . PMID 19015650.
- D'Souza, A.; J. Tseng; K. Pauly; S. Guccione; J. Rosenberg; S.S. Gambhir; G. Glazer (September 2009). "A Strategy for Blood Biomarker Amplification and Localization using Ultrasound." (PDF). PNAS. 104 (40): 17152–7. doi:10.1073/pnas.0903437106. PMC . PMID 19805109.
- Keren, S.; C. Zavaleta; Z. Cheng; A. de la Zerda; O. Gheysens; S.S. Gambhir (April 2008). "Non-invasive Molecular Imaging of Small Living Subjects Using Raman Spectroscopy." (PDF). PNAS. 105 (15): 5844–49. doi:10.1073/pnas.0710575105. PMC . PMID 18378895.
- Shipper, M.; N. Nakayama-Ratchford; C. Davis; N. Kam; P. Chu; Z. Liu; X. Sun; J. Dai; S.S. Gambhir (April 2008). "A Pilot Toxicology Study of Single-Walled Carbon Nanotubes in a Small Sample of Mice." (PDF). Nature Nanotechnology. 3 (4): 216–21. doi:10.1038/nnano.2008.68.
- Willmann, J.; N. van Bruggen; L. Dinkelborg; S.S. Gambhir (July 2008). "Molecular Imaging in Drug Development. Nature Reviews Drug Discovery, 7: 591-607, July 2008. (Cover article.)" (PDF). Nature Reviews Drug Discovery. 7 (7): 591–607. doi:10.1038/nrd2290. PMID 18591980.
- De la Zerda, A.; C. Zavaleta; S. Keren; S. Vaithilingam; S. Bodapati; Z. Liu; J. Levi; B. Smith; T. Ma; O. Oralkan; Z. Cheng; X. Chen; H. Dai; B. Khuri-Yakub; S.S. Gambhir (August 2008). "Carbon Nanotubes as Photoacoustic Molecular Imaging Agents in Living Mice." (PDF). Nature Nanotechnology. 3 (8): 557–62. doi:10.1038/nnano.2008.231. PMC . PMID 18772918.
- "Endowed professorships for Gambhir and Relman". Stanford Report. June 2009. Retrieved 2 January 2013.
- May 9, 2011 - The Dean's Newsletter - Stanford University School of Medicine
- Medical Center People
- 2004 News - MIPS: Molecular Imaging Program at Stanford - Stanford Medicine
- Gambhir Receives SMI’s Achievement Award
- Doctors win $1.5 million awards for cancer research
- Medical Center People
- College of Fellows : AIMBE
- Aebersold Award Presented to Gambhir
- ASCI - The American Society for Clinical Investigation
- Sanjiv Gambhir - Institute of Medicine
- 2009 RSNA Outstanding Researcher,
- The Gopal Subramanian Lifetime Achievement Award
- SNM’s 2011 Georg Charles de Hevesy Nuclear Pioneer Award
- Aunt Minnie Award
- Distinguished Scientist Award for Distinguished Contributions to Nuclear Medicine
- Society of Asian American Scientists in Cancer Research Award
- American Association of Indian Scientists in Cancer Research Lifetime Achievement Award
- American Association for the Advancement of Science (AAAS) Fellow Award
- J. Allyn Taylor International Prize in Medicine