It was built in the 15th century and called San Salvatore in Portico. When the church was given to the "Università dei Sarti" (the association of tailors) in 1575, the church was dedicated to their patron saint, Saint Homobonus.
Outside the church lie excavated ruins of Roman altars and temples that date from as early as the 6th century BC. The temples have been identified as those of Fortuna and Mater Matuta. The sacred area lies between the Forum Holitorium and the Forum Boarium. The archaeological site is currently under re-investigation by a joint team from the Sovraintendenza ai Beni Culturali of the Comune di Roma, the Università della Calabria, and the University of Michigan.