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Santa Elena may refer to:
- Santa Elena, Entre Ríos, a city in the province of Entre Ríos
- Costa Rica
- El Salvador
- Santa Elena, La Paz, a municipality in the Honduran department of La Paz
- Santa Elena, Paraguay, a district of the Cordillera department
- Santa Elena, Camarines Norte, a 4th-class municipality in the province of Camarines Norte
- United States
- Santa Elena de Uairén, a municipality in the state of Bolívar
| disambiguation page lists articles about distinct geographical locations with the same name.
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