Santander may refer to:
- Francisco de Paula Santander (1792–1840), a Colombian military and political leader born in Cúcuta
- Kike Santander (born 1960), a Colombian composer and record producer born in Santiago de Cali
- Gustavo Santander, Colombian composer and brother of Kike Santander
- Federico Santander, Paraguayan footballer
- Santander, Spain, the original place to receive this name, a port city and capital of the autonomous community of Cantabria, Spain
- Santander Department, a department of Colombia
- Santander State, former state of Colombia
- Santander de Quilichao, a municipality in the Cauca Department of Colombia
- Santander, Cebu, a municipality in the province of Cebu, Philippines
- Santander Group, a Spanish banking group with operations mainly in Western Europe, Latin America and United States
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