Sarah Teichmann

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Sarah Teichmann

Sarah Teichmann-ISMB2016 (28960321841).jpg
Sarah Teichmann speaking at the Intelligent Systems for Molecular Biology (ISMB) conference in 2016 in Orlando, Florida
Born
Sarah Amalia Teichmann

(1975-04-15) April 15, 1975 (age 44)[1]
Nationality
  • German
  • American[1]
  • British
EducationEuropean School, Karlsruhe
Alma materUniversity of Cambridge (BA, MA, PhD)
ChildrenTwo daughters[2][3][4]
Awards
Scientific career
Fields
Institutions
ThesisGenome evolution: analysing proteomes with new methods (1999)
Doctoral advisorCyrus Chothia[12][13]
Doctoral studentsM. Madan Babu[14]
Influences
Websiteteichlab.org

Sarah Amalia Teichmann (born 1975)[1] FMedSci[18] is Head of Cellular Genetics at the Wellcome Sanger Institute[19] and a visiting research group leader at the European Bioinformatics Institute (EMBL-EBI).[20][12] She is also a Director of Research (equivalent to Professor)[21] in the Cavendish Laboratory,[22] at the University of Cambridge and a Senior Research Fellow at Churchill College, Cambridge.[citation needed]

Education[edit]

Teichmann was educated at the European School, Karlsruhe in Germany from 1981 to 1993 where she completed the European Baccalaureate in 1993.[23] Teichmann went on to study the Natural Sciences Tripos at Trinity College, Cambridge and was awarded a first class Bachelor of Arts degree in 1996. In 1999, she completed her PhD supervised by Cyrus Chothia[24] at the Laboratory of Molecular Biology (LMB) on genome evolution.[25]

Career and research[edit]

Following her PhD, Teichmann did postdoctoral research supervised by Janet Thornton at University College London[20] and funded by the Beit Memorial Fellowships for Medical Research. From 2001-2012, she was a Medical Research Council (MRC) Programme Leader, studying patterns in protein interactions and transcriptional regulatory networks.[26][27]

In 2013 Teichmann was appointed a joint position at the Wellcome Trust Sanger Institute and the European Bioinformatics Institute (EMBL-EBI). From 2005 to 2015 she was a teaching fellow and Director of Studies at Trinity College, Cambridge. Since 2016 Teichmann has served as the head of Cellular Genetics at the Wellcome Trust Sanger Institute[19] and a visiting research group leader at the EBI.[12]

Teichmann's research[28][29][30][31] investigates gene expression[32][33][34] and protein complex assembly[35] using both wet laboratory and computational biology techniques.[36] In particular her research group:

Teichmann's research has been funded by the European Research Council (ERC), the Medical Research Council (MRC), the Biotechnology and Biological Sciences Research Council (BBSRC),[38] the Wellcome Trust, the European Molecular Biology Organization (EMBO), the Framework Programmes for Research and Technological Development and the European Cooperation in Science and Technology (COST).[23]

As of 2015 Teichmann has supervised several PhD students to completion[39][23][14][40][41][42][43][44][45][46] and several postdoctoral researchers who have gone on to become Principal investigators (PIs).[23][47][48][49]

Awards and honours[edit]

Teichmann has won a number of awards. In 2010, she was awarded Colworth Medal from the Biochemical Society.[16][50] In 2012, Teichman was awarded the Francis Crick Medal and Lecture, membership of the European Molecular Biology Organization (EMBO)[7] and the Lister Prize from the Lister Institute of Preventive Medicine.[6] In 2015 she was awarded the Michael and Kate Bárány Award for young investigators by the Biophysical Society[51] and the EMBO Gold Medal. Teichmann was elected a Fellow of the Academy of Medical Sciences (FMedSci) in 2015. Her citation on election reads:

Teichmann has also been an activist for women's careers in science through enabling scientists in families to advance their careers while working part-time.[17] She chaired a Sex in Science debate at the Wellcome Trust on balancing family life with working in research.[citation needed] Teichmann was elected an ISCB Fellow in 2016 by the International Society for Computational Biology.[10]

Personal life[edit]

Teichmann has two daughters.[2][4] Teichmann is the co-author of the children's language education novel Teenage Detectives,[52] which she wrote as a teenager together with her mother Dr. Virginia Teichmann, an English-language university lecturer in Karlsruhe.[53]

References[edit]

  1. ^ a b c Teichmann, Sarah (2007). "Sarah Amalia Teichmann PhD MA BA (Hons cantab) CV" (PDF). mrc-lmb.cam.ac.uk. Laboratory of Molecular Biology. Archived from the original (PDF) on 2013-02-26.
  2. ^ a b Greenstreet, Rosanna (2018). "Sarah Teichmann: 'I wake as early as 4am and think about work'". theguardian.com. London: The Guardian.
  3. ^ a b Marx, Vivien (2014). "The Author File: Janet Thornton". Nature Methods. 11 (2): 115. doi:10.1038/nmeth.2831.
  4. ^ a b Pain, Elisabeth (2015). "Harnessing computer power to understand biology". Science. doi:10.1126/science.caredit.a1500172.
  5. ^ Perica, Tina; Marsh, Joseph A.; Sousa, Filipa L.; Natan, Eviatar; Colwell, Lucy J.; Ahnert, Sebastian E.; Teichmann, Sarah A. (2012). "The emergence of protein complexes: quaternary structure, dynamics and allostery". Biochemical Society Transactions. 40 (3): 475–491. doi:10.1042/BST20120056. PMID 22616857.
  6. ^ a b "Dr Sarah Teichmann, EMBL-European Bioinformatics Institute & Wellcome Trust Sanger Institute". lister-institute.org.uk. Archived from the original on 2014-10-15.
  7. ^ a b "Sarah A. Teichmann EBI, Cambridge (Hinxton), United Kingdom EMBO 2012". European Molecular Biology Organization. Archived from the original on 2016-01-19.
  8. ^ "Finding patterns in genes and proteins: decoding the logic of molecular interactions". Royal Society. 2012. Archived from the original on 2012-11-10.
  9. ^ Finding patterns in genes and proteins: decoding the logic of molecular interactions on YouTube, Royal Society
  10. ^ a b Anon (2017). "ISCB Fellows". iscb.org. International Society for Computational Biology. Archived from the original on 2017-03-20.
  11. ^ Sarah Teichmann publications indexed by Google Scholar Edit this at Wikidata
  12. ^ a b c "People & Groups: Sarah Teichmann, Group Leader - Teichmann research group". EMBL-EBI. 2013. Archived from the original on 2013-04-03.
  13. ^ Park, J; Teichmann, S. A.; Hubbard, T; Chothia, C (1997). "Intermediate sequences increase the detection of homology between sequences". Journal of Molecular Biology. 273 (1): 349–54. doi:10.1006/jmbi.1997.1288. PMID 9367767.
  14. ^ a b Mohan, Madan Babu (2004). Evolution of transcriptional regulatory networks. jisc.ac.uk (PhD thesis). University of Cambridge. OCLC 890159758. EThOS uk.bl.ethos.616113.
  15. ^ Teichmann, S. A.; Rison, S. C.; Thornton, J. M.; Riley, M; Gough, J; Chothia, C (2001). "The evolution and structural anatomy of the small molecule metabolic pathways in Escherichia coli". Journal of Molecular Biology. 311 (4): 693–708. CiteSeerX 10.1.1.121.1628. doi:10.1006/jmbi.2001.4912. PMID 11518524.
  16. ^ a b "Honour and heirloom for Sarah Teichmann". Laboratory of Molecular Biology. 2012. Archived from the original on 2015-03-03.
  17. ^ a b Gaskell & Kostic (2015). "The Unstoppable Sarah Teichmann on Programing, Motherhood, and Protein Complex Assembly:The Female Scientist". Cell. Archived from the original on 2016-04-15. Retrieved 2015-11-25.
  18. ^ a b Anon (2015). "Dr Sarah Teichmann FMedSci". acmedsci.ac.uk. London: Academy of Medical Sciences. Archived from the original on 2015-07-06.
  19. ^ a b "Dr Sarah Teichmann, FMedSci, Head of Cellular Genetics". Cambridge: sanger.ac.uk. Archived from the original on 2016-04-15.
  20. ^ a b Marx, Vivien (2016). "The Author File: Sarah Teichmann". Nature Methods. 13 (4): 279. doi:10.1038/nmeth.3808. ISSN 1548-7091. PMID 27203785.
  21. ^ Anon (2013). "Job titles and duties at the University of Cambridge". University of Cambridge. Archived from the original on 2013-07-03.
  22. ^ Anon (2015). "Dr Sarah Teichmann FMedSci". tcm.phy.cam.ac.uk. Cambridge. Archived from the original on 2015-09-12.
  23. ^ a b c d Anon (2015). "Sarah Teichmann: 40th FEBS Congress - The Biochemical Basis of Life - Berlin, Germany". Federation of European Biochemical Societies. Archived from the original on 2015-02-20.
  24. ^ Chothia, C; Gough, J; Vogel, C; Teichmann, S. A. (2003). "Evolution of the protein repertoire". Science. 300 (5626): 1701–3. doi:10.1126/science.1085371. PMID 12805536.
  25. ^ Teichmann, Sarah Amalia (1999). Genome evolution : analysing proteomes with new methods (PhD thesis). University of Cambridge. OCLC 894602472. EThOS uk.bl.ethos.624585.
  26. ^ Babu, M. M.; Luscombe, N. M.; Aravind, L; Gerstein, M; Teichmann, S. A. (2004). "Structure and evolution of transcriptional regulatory networks". Current Opinion in Structural Biology. 14 (3): 283–91. CiteSeerX 10.1.1.471.9692. doi:10.1016/j.sbi.2004.05.004. PMID 15193307.
  27. ^ Luscombe, N. M.; Babu, M. M.; Yu, H; Snyder, M; Teichmann, S. A.; Gerstein, M (2004). "Genomic analysis of regulatory network dynamics reveals large topological changes". Nature. 431 (7006): 308–12. doi:10.1038/nature02782. PMID 15372033.
  28. ^ Sarah A. Teichmann author profile page at the ACM Digital Library Edit this at Wikidata
  29. ^ Sarah Teichmann at DBLP Bibliography Server Edit this at Wikidata
  30. ^ Sarah Teichmann publications indexed by the Scopus bibliographic database. (subscription required)
  31. ^ Sarah Teichmann publications from Europe PubMed Central
  32. ^ Carninci, P; Kasukawa, T; Katayama, S; Gough, J; Frith, M. C.; Maeda, N; Oyama, R; Ravasi, T; Lenhard, B; Wells, C; Kodzius, R; Shimokawa, K; Bajic, V. B.; Brenner, S. E.; Batalov, S; Forrest, A. R.; Zavolan, M; Davis, M. J.; Wilming, L. G.; Aidinis, V; Allen, J. E.; Ambesi-Impiombato, A; Apweiler, R; Aturaliya, R. N.; Bailey, T. L.; Bansal, M; Baxter, L; Beisel, K. W.; Bersano, T; et al. (2005). "The transcriptional landscape of the mammalian genome". Science. 309 (5740): 1559–63. doi:10.1126/science.1112014. PMID 16141072.
  33. ^ Drosophila 12 Genomes, Consortium; Clark, A. G.; Eisen, M. B.; Smith, D. R.; Bergman, C. M.; Oliver, B; Markow, T. A.; Kaufman, T. C.; Kellis, M; Gelbart, W; Iyer, V. N.; Pollard, D. A.; Sackton, T. B.; Larracuente, A. M.; Singh, N. D.; Abad, J. P.; Abt, D. N.; Adryan, B; Aguade, M; Akashi, H; Anderson, W. W.; Aquadro, C. F.; Ardell, D. H.; Arguello, R; Artieri, C. G.; Barbash, D. A.; Barker, D; Barsanti, P; Batterham, P; et al. (2007). "Evolution of genes and genomes on the Drosophila phylogeny". Nature. 450 (7167): 203–18. doi:10.1038/nature06341. PMID 17994087.
  34. ^ Wilson, D; Charoensawan, V; Kummerfeld, S. K.; Teichmann, S. A. (2008). "DBD--taxonomically broad transcription factor predictions: New content and functionality". Nucleic Acids Research. 36 (Database issue): D88–92. doi:10.1093/nar/gkm964. PMC 2238844. PMID 18073188.
  35. ^ Levy, E. D.; Teichmann, S (2013). "Structural, Evolutionary, and Assembly Principles of Protein Oligomerization". Oligomerization in Health and Disease. Progress in Molecular Biology and Translational Science. 117. pp. 25–51. doi:10.1016/B978-0-12-386931-9.00002-7. ISBN 9780123869319. PMID 23663964.
  36. ^ Perica, T; Kondo, Y; Tiwari, S. P.; McLaughlin, S. H.; Kemplen, K. R.; Zhang, X; Steward, A; Reuter, N; Clarke, J; Teichmann, S. A. (2014). "Evolution of oligomeric state through allosteric pathways that mimic ligand binding". Science. 346 (6216): 1254346. doi:10.1126/science.1254346. PMC 4337988. PMID 25525255.
  37. ^ "Teichmann group Research EMBL-EBI". European Bioinformatics Institute. 2013. Archived from the original on 2013-04-02.
  38. ^ Anon (2015). "UK Government research grants awarded to Sarah Teichmann". Research Councils UK. Archived from the original on 2015-03-03.
  39. ^ Teichmann, Sarah (2015). "Alumni from Sarah Teichmann's Group". European Bioinformatics Institute. Archived from the original on 2015-02-20.
  40. ^ Charoensawan, Varodom (2011). Evolution and dynamics of transcription factors and gene expression patterns. ethos.bl.uk (PhD thesis). University of Cambridge. OCLC 890150091.
  41. ^ De, Subhajyoti (2008). Human genome evolution : investigating protein divergence, polymorphisms and genomic neighbourhood. ethos.bl.uk (PhD thesis). University of Cambridge. OCLC 890154864.
  42. ^ Han, Jay (2007). Structure, function and evolution of protein-protein interactions (PhD thesis). University of Cambridge.
  43. ^ Kummerfeld, Sarah Kay (2006). Towards understanding the protein universe : genome-scale studies of evolution and gene regulation. ethos.bl.uk (PhD thesis). University of Cambridge.
  44. ^ Levy, Emmanuel Doram (2008). Classification, evolution, and assembly of protein complexes. ethos.bl.uk (PhD thesis). University of Cambridge.
  45. ^ Perica, Tina (2013). Evolutionary and structural dynamics of protein complexes (PhD thesis). University of Cambridge. OCLC 890148231.
  46. ^ Su, Jing (2012). Computational prediction of regulatory elements (PhD thesis). University of Cambridge.
  47. ^ Adryan, B; Teichmann, S. A. (2010). "The developmental expression dynamics of Drosophila melanogaster transcription factors". Genome Biology. 11 (4): R40. doi:10.1186/gb-2010-11-4-r40. PMC 2884543. PMID 20384991.
  48. ^ Gsponer, J; Futschik, M. E.; Teichmann, S. A.; Babu, M. M. (2008). "Tight regulation of unstructured proteins: From transcript synthesis to protein degradation". Science. 322 (5906): 1365–8. doi:10.1126/science.1163581. PMC 2803065. PMID 19039133.
  49. ^ Hebenstreit, D; Gu, M; Haider, S; Turner, D. J.; Liò, P; Teichmann, S. A. (2011). "EpiChIP: Gene-by-gene quantification of epigenetic modification levels". Nucleic Acids Research. 39 (5): e27. doi:10.1093/nar/gkq1226. PMC 3061070. PMID 21131282.
  50. ^ Anon (2015). "Women at Cambridge: Sarah Amalia Teichmann". University of Cambridge. Archived from the original on 2015-02-20.
  51. ^ "Biophysical Society Names 2015 Award Recipients" (PDF). Biophysical Society.
  52. ^ Teichmann, Sarah; Teichmann, Virginia (1991). Cornelsen English Library - Fiction: 8. Schuljahr, Stufe 1 - Teenage Detectives: Textheft. Mit Aufgaben und Activities. Germany: Cornelsen Verlag. ISBN 978-3464053362.
  53. ^ "The Honeycomb: Dr. Virginia Teichmann: Word Lover" (PDF). Retrieved 2015-12-07.