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Sarsaparilla may refer to:
- Several species of plants, of the genus Smilax, including:
- Other plant species known by the same name include:
- Sarsaparilla (soft drink), made or flavored with the root of these plants
- Sassparilla (band), Portland, Oregon-based roots-rock band
- Jade and Sarsaparilla, American musical act of the 1970s
| disambiguation page lists articles associated with the title Sarsaparilla.
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