"Scar Tissue" has been a live staple in the band's setlists since its first performance in 1998 making it the band's third most performed song ever behind only "Give It Away" and "Under the Bridge".
In 2004 Anthony Kiedis published Scar Tissue. Co-written by Larry Sloman, it was an autobiography with the principal theme of sex, drugs and rock-'n-roll. In the book he talks about the consequences of drugs (especially heroin) and in which way this can destroy somebody's life.
The opening shot is of John Frusciante driving, a metaphor for Frusciante's return to the band (he does not drive in real life). But the four of them are battered, beaten and bandaged. They are traveling in a rusty wreck and playing broken instruments on the comeback trail. The video ends after an emotional thirty second Frusciante guitar solo at the moment of sunset, with John tossing the broken guitar from the car. The car Frusciante drove for the video was a 1967 Pontiac Catalina convertible. A very similar concept was considered, then scrapped, for the earlier "Soul to Squeeze" video. Prior to the video shoot Kiedis had his hair cut and dyed his brown hair platinum blond.