Schlosser's base

From Wikipedia, the free encyclopedia
Jump to: navigation, search

Schlosser's base describes various superbasic mixtures of an alkyllithium compound and a potassium alkoxide. Commonly, the mixture is produced by combining n-butyllithium and potassium tert-butoxide in a one-to-one ratio. The reagent is named after Manfred Schlosser, although he uses the term LICKOR superbase (LIC denoting the alkyllithium, and KOR denoting the potassium alkoxide). The reagent acts by formation of the organopotassium compound, which are very strong bases. Potassium benzyl is prepared from toluene using this reagent.

Further reading[edit]

  • Schlosser, Manfred (1988). "Superbases for organic synthesis". Pure and Applied Chemistry. 60 (11): 1627–1634. doi:10.1351/pac198860111627. 
  • Schlosser, Manfred (2005-01-07). "The 2×3 Toolbox of Organometallic Methods for Regiochemically Exhaustive Functionalization". Angewandte Chemie International Edition. 44 (3): 376–393. doi:10.1002/anie.200300645. PMID 15558637.