Sciotoville is a populated place in the city of Portsmouth in Scioto County, Ohio. It is located at the intersection of U.S. 52 and State Route 335 between the village of New Boston and Wheelersburg in Scioto County along the northern bank of the Ohio River. It has its own post office, but shares the Zip code of 45662 zip code with the city of Portsmouth.
Sciotoville was founded in 1835 and platted in 1841 by William Brown. It was annexed by the city of Portsmouth in 1921.
The residents of Sciotoville are served educationally by both the Portsmouth City School District and the Sciotoville Community School. Their library needs are provided by the Portsmouth Public Library (located in downtown Portsmouth), with branches in nearby New Boston, South Webster, and Wheelersburg. Sciotoville is also served by the Portsmouth Fire Department. A station is located on Harding Avenue.