Scombroid food poisoning

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Scombroid food poisoning
Histamine 3D ball.png
Classification and external resources
Specialty emergency medicine
ICD-10 T61.1
ICD-9-CM 988.0
DiseasesDB 31114
eMedicine emerg/523

Scombroid food poisoning is a foodborne illness that results from eating spoiled (decayed) fish.[1] Along with ciguatera, it is listed as a common type of seafood poisoning.[2] The toxin believed to be responsible is histamine, formed as the flesh of the fish begins to decay. As histamine is also the natural agent involved in allergic reactions, scombroid food poisoning often gets misidentified as a food allergy.

The syndrome is named after Scombridae family of fish, which includes mackerels, tunas and bonitos, because early descriptions of the illness noted an association with those species; however, the Centers for Disease Control and Prevention (CDC) have identified other, nonscombroid vectors, such as mahi-mahi and amberjack. Scombroid syndrome can result from inappropriate handling of fish during storage or processing. Cooking the food does not prevent illness, because histamine is not destroyed at normal cooking temperatures.


Unlike many types of food poisoning, Scombroid form is not brought about by ingestion of a pathogen.[1] Histidine is an amino acid that exists naturally in many types of food (including fish) and at temperatures above 16°C/60°F it is converted to the biogenic amine histamine via the enzyme histidine decarboxylase produced by symbiotic bacteria such as Morganella morganii (this is one reason why fish should be stored in the freezer). Histamine is not destroyed by normal cooking temperatures, so even properly cooked fish can still result in poisoning.[3] Histamine is the main natural chemical responsible for true allergic reactions, so the symptoms produced are almost identical to a food allergy.[4][5]


Symptoms typically occur within 10–30 minutes of ingesting the fish and generally are self-limited. People with asthma are more vulnerable to respiratory problems such as wheezing or bronchospasms. However, symptoms may show over two hours after consumption of a spoiled dish. They usually last for about 10 to 14 hours, and rarely exceed one to two days.


The first signs of poisoning suggest an allergic reaction with the following symptoms:

  • facial flushing/sweating
  • burning-peppery taste sensations in the mouth and throat
  • dizziness
  • nausea
  • headache
  • tachycardia
  • cold-like symptoms

Additional symptoms[edit]

The above symptoms can advance to:

  • facial rash
  • torso or body rash: The rash associated with scombroid poisoning is a form of urticaria, but most commonly does not include wheals (patchy areas of skin-swelling also known as hives) that may be seen in true allergies.[6]
  • edema (this is generalized if it occurs at all)
  • short-term diarrhea
  • abdominal cramps


In the worst cases, the poisoning may cause:

  • blurred vision
  • respiratory distress
  • swelling of the tongue

In rare cases, the poisoning may result in death. The coroner's report on Noelene and Yvana Bischoff, mother and daughter tourists from Australia who died suddenly in Bali in January 2014, concluded their deaths were caused by scombroid food poisoning.[7]


Treatment is in the form of supportive care. If there is light-headedness, the victim should lie with feet partly elevated. If there is severe wheezing, then intramuscular epinephrine should be given, 0.5–1 ml at dilution of 1/1000 (standard medical emergency kit). An oral or intra-venous antihistamine should be given if needed.


  1. ^ a b Clark RF, Williams SR, Nordt SP, Manoguerra AS (1999). "A review of selected seafood poisonings". Undersea Hyperb Med 26 (3): 175–84. PMID 10485519. Retrieved 2008-08-12. 
  2. ^ "Poisoning - fish and shellfish". MedlinePlus - National Institutes of Health's Web site. Retrieved 6 September 2012. 
  3. ^ Benner, Ronald A. "Scombrotoxin". Bad Bug Book: Foodborne Pathogenic Microorganisms and Natural Toxins (PDF). U.S. Food and Drug Administration. 
  4. ^ Otwell, W. Steven (2015-06-24). "Scombrotoxin Poisoning and Decomposition". U.S. Food and Drug Administration. Retrieved 2016-09-23.  Check date values in: |access-date= (help)
  5. ^ Barry Leonard (August 2011). Fish and Fishery Products: Hazards and Controls Guidance (4th Ed. ) (PDF). DIANE Publishing. pp. 113–. ISBN 978-1-4379-8746-1. 
  6. ^ "Scombroid fish poisoning". DermNet New Zealand Trust. 15 December 2014. 
  7. ^ "Non-inquest findings into the death of Noelene Gaye BISCHOFF and Yvana Jean Yuri BISCHOFF" (PDF). 30 March 2015. 

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