In 2005, Klopfenstein moved to New York City to live with his fiancée. In September, he was diagnosed with Guillain-Barré syndrome while touring New Zealand with Reel Big Fish. Klopfenstein was hospitalized immediately, and sent home to New York to recover. He rejoined the band for a New Year's Eve concert that year. Shortly afterward, while touring in Europe, Klopfenstein had a relapse and was flown home from Amsterdam, unable to finish the rest of the tour. He subsequently returned to the band's lineup.
Klopfenstein retired from Reel Big Fish at the end of 2011, before the birth of his first child.
In concert, Klopfenstein talks to the audience frequently and participates in humorous banter with Barrett. Once, in an interview, he summed himself up in 5 words: Good Funky, Sexy, Chicken Fingers.