Born in Comunanza near Ascoli Piceno, he traveled to Bologna, where he derived instruction in design from Guercino. He however became more popular as an architect. He was named Papal engineer by Pope Urban VIII, and awarded a knighthood of the Cross. His son Giuseppe was known as a painter; his grandson, Pier Leone, has become known for his ink caricatures. Sebastiano frescoed the lunettes (1612–1613) in the cloister of S. Domenico in Ascoli, where he left a self-portrait. The frescoes are now significantly decayed. He also painted the main altar for the church of San Francesco in Comunanza.
- Rosini, Giovanni (1847). Storia della Pittura Italiana esposta coi Monumenti, (Época Quarta: dal Carracci all'Appiani); Volume VII. Pisa; Original from Oxford University digitized Jan 4, 2007: Niccolò Capurro. p. 83.
- Guide to Ghezzi nelle Marche.
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