|2nd Minister of Health of Eritrea|
|Preceded by||Haile Mehtsun|
|Succeeded by||Saleh Meki|
|3rd Minister of Defence of Eritrea|
1995 – present
|Preceded by||Mesfin Hagos|
[Abardae, Eritrea ኣባርዳአ,ኤርትራ]] 
Sebhat Ephrem (Tigrinya: ሰብሓት ኤፍረም; b. 1951, Abardae,Eritrea) is the Minister of Energy and Mines for Eritrea, a former Minister of Defence and former Eritrean People's Liberation Front commander during the Eritrean War of Independence.
Sebhat attended high school at the Evangelical Lutheran High School in Asmara, Eritrea. Sebhat Ephrem served from June 1992 to March 1994 as the Governor of Asmara. From March 1994 to May 1995 he served as the Minister of Health. In both positions he brought structure and reorganization to these offices. After leaving the military in June 1992, he returned to the army in May 1995 with the rank of general and was appointed and confirmed as Minister of Defense. It is believed that he is the only 4-star general in Eritrean defence forces yet.
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