|3rd Minister of Defence of Eritrea|
|Preceded by||Mesfin Hagos|
|2nd Minister of Health of Eritrea|
|Preceded by||Haile Mehtsun|
|Succeeded by||Saleh Meki|
|Born||1951 (age 65–66)
[Abardae, Eritrea ኣባርዳአ,ኤርትራ]] 
Sebhat Ephrem (Tigrinya: ሰብሓት ኤፍረም; born 1951 in Abardae, Eritrea) is the Minister of Energy and Mines for Eritrea, a former Minister of Defence and former Eritrean People's Liberation Front commander during the Eritrean War of Independence.
Sebhat completed high school at the Evangelical Lutheran High School in Asmara, Eritrea. He later attended Addis Ababa University for two years before joining the EPLF in 1972. As a fighter, he quickly rose up the ranks from a political commissar to becoming part of the executive committee. Sebhat Ephrem served from June 1992 to March 1994 as the Governor of Asmara. From March 1994 to May 1995 he served as the Minister of Health. In both positions he brought structure and reorganization to these offices. After leaving the military in June 1992, he returned to the army in May 1995 with the rank of general and was appointed and confirmed as Minister of Defense. It is believed that he is the only 4-star general in the Eritrean defence forces thus far.
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