Secoisolariciresinol dehydrogenase

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Secoisolariciresinol dehydrogenase
Identifiers
EC number 1.1.1.331
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Secoisolariciresinol dehydrogenase (EC 1.1.1.331) is an enzyme with systematic name (-)-secoisolariciresinol:NAD+ oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reaction

(-)-secoisolariciresinol + 2 NAD+ (-)-matairesinol + 2 NADH + 2 H+

This enzyme is isolated from the plants Forsythia intermedia and Podophyllum peltatum.

References[edit]

  1. ^ Xia, Z.Q., Costa, M.A., Pelissier, H.C., Davin, L.B. and Lewis, N.G. (2001). "Secoisolariciresinol dehydrogenase purification, cloning, and functional expression. Implications for human health protection". J. Biol. Chem. 276 (16): 12614–12623. PMID 11278426. doi:10.1074/jbc.M008622200. 
  2. ^ Youn, B., Moinuddin, S.G., Davin, L.B., Lewis, N.G. and Kang, C. (2005). "Crystal structures of apo-form and binary/ternary complexes of Podophyllum secoisolariciresinol dehydrogenase, an enzyme involved in formation of health-protecting and plant defense lignans". J. Biol. Chem. 280 (13): 12917–12926. PMID 15653677. doi:10.1074/jbc.M413266200. 
  3. ^ Moinuddin, S.G., Youn, B., Bedgar, D.L., Costa, M.A., Helms, G.L., Kang, C., Davin, L.B. and Lewis, N.G. (2006). "Secoisolariciresinol dehydrogenase: mode of catalysis and stereospecificity of hydride transfer in Podophyllum peltatum". Org. Biomol. Chem. 4 (5): 808–816. PMID 16493463. doi:10.1039/b516563f. 

External links[edit]