Second Amendment may refer to:
- Second Amendment to the United States Constitution, part of the United States Bill of Rights, protecting the right of the people to keep and bear arms
- Colorado Amendment 2 of the state constitution (1992), which was the subject of the United States Supreme Court case Romer v. Evans
- Florida Amendment 2 (2008), an amendment to the Constitution of Florida that prohibited same-sex marriage.
- Second Amendment of the Constitution of Ireland, an omnibus amendment
- Second Amendment of the Constitution of South Africa, which made various technical changes
- Australian referendum, 1910 (State Debts), the second amendment to the Constitution of Australia
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