Secretin receptor

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Secretin receptor
Symbols SCTR ; SR
External IDs OMIM182098 HomoloGene68290 IUPHAR: 252 ChEMBL: 1925 GeneCards: SCTR Gene
RNA expression pattern
PBB GE SCTR 210382 at tn.png
More reference expression data
Species Human Mouse
Entrez 6344 319229
Ensembl ENSG00000080293 ENSMUSG00000026387
UniProt P47872 Q5FWI2
RefSeq (mRNA) NM_002980 NM_001012322
RefSeq (protein) NP_002971 NP_001012322
Location (UCSC) Chr 2:
119.44 – 119.53 Mb
Chr 1:
120.01 – 120.06 Mb
PubMed search [1] [2]

Human secretin receptor (gene name SCTR) is a G protein-coupled receptor which binds secretin and is the leading member (i.e., first cloned) of the class B GPCR subfamily.[1]


Secretin receptor has been shown to interact with Pituitary adenylate cyclase activating peptide.[2]


  1. ^ Dong M, Miller LJ (2002). "Molecular pharmacology of the secretin receptor". Recept. Channels 8 (3–4): 189–200. doi:10.1080/10606820213686. PMID 12529936. 
  2. ^ Felley, C P; Qian J M; Mantey S; Pradhan T; Jensen R T (Dec 1992). "Chief cells possess a receptor with high affinity for PACAP and VIP that stimulates pepsinogen release". Am. J. Physiol. (UNITED STATES) 263 (6 Pt 1): G901–7. ISSN 0002-9513. PMID 1335692. 

Further reading[edit]

  • Ulrich CD, Holtmann M, Miller LJ (1998). "Secretin and vasoactive intestinal peptide receptors: members of a unique family of G protein-coupled receptors". Gastroenterology 114 (2): 382–97. doi:10.1016/S0016-5085(98)70491-3. PMID 9453500. 
  • Felley CP, Qian JM, Mantey S, et al. (1993). "Chief cells possess a receptor with high affinity for PACAP and VIP that stimulates pepsinogen release". Am. J. Physiol. 263 (6 Pt 1): G901–7. PMID 1335692. 
  • Ishihara T, Nakamura S, Kaziro Y, et al. (1991). "Molecular cloning and expression of a cDNA encoding the secretin receptor". EMBO J. 10 (7): 1635–41. PMC 452832. PMID 1646711. 
  • Robberecht P, De Neef P, Waelbroeck M, et al. (1988). "Secretin receptors in human pancreatic membranes". Pancreas 3 (5): 529–35. doi:10.1097/00006676-198810000-00004. PMID 3186683. 
  • Chow BK (1995). "Molecular cloning and functional characterization of a human secretin receptor". Biochem. Biophys. Res. Commun. 212 (1): 204–11. doi:10.1006/bbrc.1995.1957. PMID 7612008. 
  • Patel DR, Kong Y, Sreedharan SP (1995). "Molecular cloning and expression of a human secretin receptor". Mol. Pharmacol. 47 (3): 467–73. PMID 7700244. 
  • Holtmann MH, Hadac EM, Miller LJ (1995). "Critical contributions of amino-terminal extracellular domains in agonist binding and activation of secretin and vasoactive intestinal polypeptide receptors. Studies of chimeric receptors". J. Biol. Chem. 270 (24): 14394–8. doi:10.1074/jbc.270.24.14394. PMID 7782300. 
  • Jiang S, Ulrich C (1995). "Molecular cloning and functional expression of a human pancreatic secretin receptor". Biochem. Biophys. Res. Commun. 207 (3): 883–90. doi:10.1006/bbrc.1995.1268. PMID 7864894. 
  • Sreedharan SP, Patel DR, Huang JX, Goetzl EJ (1993). "Cloning and functional expression of a human neuroendocrine vasoactive intestinal peptide receptor". Biochem. Biophys. Res. Commun. 193 (2): 546–53. doi:10.1006/bbrc.1993.1658. PMID 8390245. 
  • Mark HF, Chow BK (1996). "Localization of the gene encoding the secretin receptor, SCTR, on human chromosome 2q14.1 by fluorescence in situ hybridization and chromosome morphometry". Genomics 29 (3): 817–8. doi:10.1006/geno.1995.9922. PMID 8575789. 
  • Vilardaga JP, di Paolo E, de Neef P, et al. (1996). "Lysine 173 residue within the first exoloop of rat secretin receptor is involved in carboxylate moiety recognition of Asp 3 in secretin". Biochem. Biophys. Res. Commun. 218 (3): 842–6. doi:10.1006/bbrc.1996.0150. PMID 8579602. 
  • Chow BK (1998). "Functional antagonism of the human secretin receptor by a recombinant protein encoding the N-terminal ectodomain of the receptor". Receptors & signal transduction 7 (3): 143–50. PMID 9440501. 
  • Shetzline MA, Premont RT, Walker JK, et al. (1998). "A role for receptor kinases in the regulation of class II G protein-coupled receptors. Phosphorylation and desensitization of the secretin receptor". J. Biol. Chem. 273 (12): 6756–62. doi:10.1074/jbc.273.12.6756. PMID 9506976. 
  • Ho PK, Fong RS, Kai HS, et al. (1999). "The human secretin receptor gene: genomic organization and promoter characterization". FEBS Lett. 455 (3): 209–14. doi:10.1016/S0014-5793(99)00864-9. PMID 10437774. 
  • Pang RT, Ng SS, Cheng CH, et al. (1999). "Role of N-linked glycosylation on the function and expression of the human secretin receptor". Endocrinology 140 (11): 5102–11. doi:10.1210/en.140.11.5102. PMID 10537138. 
  • Chan KY, Pang RT, Chow BK (2001). "Functional segregation of the highly conserved basic motifs within the third endoloop of the human secretin receptor". Endocrinology 142 (9): 3926–34. doi:10.1210/en.142.9.3926. PMID 11517171. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Pang RT, Lee LT, Ng SS, et al. (2004). "CpG methylation and transcription factors Sp1 and Sp3 regulate the expression of the human secretin receptor gene". Mol. Endocrinol. 18 (2): 471–83. doi:10.1210/me.2003-0245. PMID 14645499. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 

External links[edit]