The first single, "See Me Shine", featuring Lyfe Jennings and Jay Rush, was produced and co-written by Excel Beats who was also the original creator of the song which was created in 2005. It was released by Bone on October 20, 2009. The second single from the album was "Rebirth", featuring Thin C, released on February 15, 2010. The song was produced by Pooh Bear and King David. The third single, "Meet Me in the Sky", was released on March 22, 2010. "Gangsta's Glory" was released as a free download on the group's official website on January 28, 2010. The song was produced by Matt Velo. The album version of "See Me Shine" is different from the earlier released single version, in that it does not feature Phaedra and Lyfe Jennings.
On November 28, 2008, all five members performed live at an event at Club Nokia in Los Angeles for the first time since Flesh's incarceration. The event was sold out and thousands of fans listened to the group perform memorable songs from several of their albums, including unreleased music. Later that night on the groups MySpace page, a bulletin press release was posted, finally announcing the official release date of their new album project, Uni-5. The Uni-5 project has been a movement started by the group after Flesh-n-Bone, one of the original members, was released from prison on July 13, 2008 and reuniting with the group. The album had an initial release date of September 22, 2009 but had been pushed back several months. Layzie confirmed that the album should be out on May 4, 2010. In an exclusive interview on HipHopDX.com, Bizzy Bone was enthusiastic about the new musical style with 10-20 tracks recorded and over 200 tracks already being completed. They have left their label, Interscope Records, to form under a brand new label distributed by Warner Bros. called Bone Thugs-N-Harmony Worldwide, which is where the new album "Uni-5: The World's Enemy" was produced and released.
Uni5 received mixed to positive reviews from music critics. XXL Magazine gave it an XL rating, while the allmusic.com gave the album 3 1/2 stars. HipHopDX also gave Uni5 3 1/2 stars stating "If BTNH over a different type of backdrop (thus providing more variety to their catalog) is what a listener was after, then Uni-5 will be satisfying. If someone wants another taste of Creepin on ah Come Up, the group's latest will only feel average in comparison." David Jeffries of Allmusic illustrated in a 3 1/2 star rated review "With estranged brother Bizzy back in the fold, Uni5: The World's Enemy reunites the original five members of Bone Thugs-N-Harmony after 10 years apart, but it’s not a return to form by any stretch of the imagination. This eighth studio effort leans toward radio-friendly numbers and proper grown-man tracks, with the core four members offering life lessons as Bizzy gives his Biblical perspective. The closest they come to the old days is the opening, “Rebirth,” a chugging juggernaut of an anthem that mixes thunderous production with a hook-filled chorus and those quick, whip-snap verses Bone built their name on. Momentum builds as the album’s lyrical highlight “See Me Shine” gives way to the dark, cursed, and Bizzy-less “Only God Can Judge Me,” which features gospel choir singers and demonic voices melting into a truly unsettling production. “Wanna Be” is bland until Bizzy’s grand moment comes while damning the music industry with “I see women given their bodies like David Letterman love you/Strugglin’ and Husslin’, slangin’ tapes on the Internet” then “Sorry I meant to tell you just what just masters do” and exiting on “Only Jesus can make you a star.” His interests are obviously elsewhere as the rest of Bone try to craft a veteran hip-hop album that can crossover, but Bizzy acting as the group’s mystical and mysterious Flavor Flav is an interesting twist, and he lights every track he lands on. Krayzie Bone's contribution is worth mentioning as he turns in a handful of innovative productions, but the prize goes to producer and Mo Thugs associate Thin C and his mellow, smoker’s delight “My Life.” Like so many family reunions the album is a mix of naturally flowing moments and awkward ones, but when it clicks, that Bone magic is, in effect, making this a necessary listen for the faithful."