Selenophosphate synthetase 1

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Selenophosphate synthetase 1
Protein SEPHS1 PDB 3FD5.png
Rendering based on PDB 3FD5.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SEPHS1 ; SELD; SPS; SPS1
External IDs OMIM600902 MGI1923580 HomoloGene56558 GeneCards: SEPHS1 Gene
EC number
RNA expression pattern
PBB GE SEPHS1 208939 at tn.png
PBB GE SEPHS1 208940 at tn.png
PBB GE SEPHS1 208941 s at tn.png
More reference expression data
Species Human Mouse
Entrez 22929 109079
Ensembl ENSG00000086475 ENSMUSG00000026662
UniProt P49903 Q8BH69
RefSeq (mRNA) NM_001195602 NM_175400
RefSeq (protein) NP_001182531 NP_780609
Location (UCSC) Chr 10:
13.32 – 13.35 Mb
Chr 2:
4.88 – 4.91 Mb
PubMed search [1] [2]

Selenide, water dikinase 1 is an enzyme that in humans is encoded by the SEPHS1 gene.[1][2]

This protein encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons.[2]


  1. ^ Low SC, Harney JW, Berry MJ (Oct 1995). "Cloning and functional characterization of human selenophosphate synthetase, an essential component of selenoprotein synthesis". J Biol Chem 270 (37): 21659–64. doi:10.1074/jbc.270.37.21659. PMID 7665581. 
  2. ^ a b "Entrez Gene: SEPHS1 selenophosphate synthetase 1". 

Further reading[edit]