Semantic dementia

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Semantic dementia
Classification and external resources
SpecialtyNeurology, Psychiatry
MeSHD003704

Semantic dementia (SD), also known as semantic variant primary progressive aphasia (svPPA), is a progressive neurodegenerative disorder characterized by loss of semantic memory in both the verbal and non-verbal domains. However, the most common presenting symptoms are in the verbal domain (with loss of word meaning).[1][2][3] SD is one of the three canonical clinical syndromes associated with frontotemporal lobar degeneration (FTLD), with the other two being frontotemporal dementia and progressive nonfluent aphasia. SD is a clinically defined syndrome, but is associated with predominantly temporal lobe atrophy (left greater than right) and hence is sometimes called temporal variant FTLD (tvFTLD).[4] SD is one of the three variants of Primary Progressive Aphasia (PPA), which results from neurodegenerative disorders such as FTLD or Alzheimer's disease. It is important to note the distinctions between Alzheimer’s Disease and Semantic dementia with regard to types of memory affected. In general, Alzheimer’s Disease is referred to as disorder affecting mainly episodic memory, defined as the memory related to specific, personal events distinct for each individual. Semantic dementia generally affects semantic memory, which refers to long-term memory that deals with common knowledge and facts.3

It was first described by Arnold Pick in 1904 and in modern times was characterized by Professor Elizabeth Warrington in 1975,[5] but it was not given the name semantic dementia until 1989.[6] The clinical and neuropsychological features, and their association with temporal lobe atrophy were described by Professor John Hodges and colleagues in 1992.[7]

Semantic Deficits[edit]

The defining characteristic of SD is decreased performance on tasks that require semantic memory. This includes difficulty with naming pictures and objects, single word comprehension, categorizing, and knowing uses and features of objects. SD patients also have difficulty with spontaneous speech creation, using words such as "this" or "things" where more specific and meaningful words can be used.[2] Syntax is spared, and SD patients have the ability to discern syntactic violations and comprehend sentences with minimal lexical demands.[8] SD patients have selectively worse concrete word knowledge and association, but retain knowledge and understanding of abstract words.[9] SD patients are able to retain knowledge of numbers and music, but have more difficulty with concrete concepts with visual associations.[2] Impairments of processing of phonemic structure and prosodic predictability have also been observed.[10]

Physical Changes[edit]

Structural and functional MRI imaging show a characteristic pattern of atrophy in the temporal lobes (predominantly on the left), with inferior greater than superior involvement and anterior temporal lobe atrophy greater than posterior. This distinguishes it from Alzheimer's disease.[11] Meta-analyses on MRI and FDG-PET studies confirmed these findings by identifying alterations in the inferior temporal poles and amygdalae as the hotspots of disease - brain regions that have been discussed in the context of conceptual knowledge, semantic information processing, and social cognition.[12] Based on these imaging methods, semantic dementia can be regionally dissociated from the other subtypes of frontotemporal lobar degeneration, frontotemporal dementia, and progressive nonfluent aphasia.

Selective hypometabolism of glucose has been observed in the anterior temporal lobe, as well as the medial temporal lobe and limbic areas.[13]

Damage to white matter tracts connecting the anterior temporal cortex to the inferior longitudinal, arcuate, and uncinate fasciculi, which are regions of the language network, is also seen using diffusion tensor imaging.[2] Imaging also shows the integrity of the axonal connections from the anterior temporal cortex to frontal and posterior associative areas to be altered.[13]

Functional abnormalities have also been observed in hippocampal structures, the ventromedial prefrontal cortex, and the cingulate cortex.[13]

Diagnosis and Performance[edit]

SD patients generally have difficulty generating familiar words or recognizing familiar objects and faces.[14] Clinical signs include fluent aphasia, anomia, impaired comprehension of word meaning, and associative visual agnosia (inability to match semantically related pictures or objects). As the disease progresses, behavioral and personality changes are often seen similar to those seen in frontotemporal dementia.[14]

SD patients perform poorly on tests of semantic knowledge. Published tests include both verbal and non-verbal tasks, e.g., The Warrington Concrete and Abstract Word Synonym Test,[15] and The Pyramids and Palm Trees task.[7] Testing also reveals deficits in picture naming (e.g. "dog" for a picture of a hippopotamus) and decreased category fluency. The question "What is a Stapler?" has been used as a primary diagnostic technique for discerning how SD patients understand word meaning.[2]

Speech of SD patients is marked by word-finding pauses, reduced frequency of content words, semantic paraphasias, circumlocutions, increased ratios of verbs to nouns, increased numbers of adverbs, and multiple repeats.[16]

SD patients sometimes show symptoms of surface dyslexia, a relatively selective impairment in reading low-frequency words with exceptional or atypical spelling-to-sound correspondences.[2]

It is currently unknown why semantic memory is impaired and semantic knowledge deteriorates in SD patients, though the cause may be due to damage to an amodal semantic system. This theory is supported by the atrophy of the anterior temporal lobe, which is believed to contain a component of the semantic system that integrates conceptual information. Others hypothesize that the damage is predominantly to the ventral temporal cortex, since SD patients remember numbers and music, but have trouble associating visual cues to concrete words.[2]

Due to the variety of symptoms dementia patients present, it becomes more difficult to assess semantic memory capability especially with regard to musical elements. In order to circumvent the explicit verbal learning tests for dementia, semantic melodic matching is a useful technique for detecting the semantic memory of semantic dementia patients.[17] Moreover, it is important to maintain that these tests must be compared to nonmusical domain tests, as there music cognition is not often measured in semantic dementia patients (less data available).

Genetics[edit]

The majority of SD patients have ubiquitin-positive, TDP-43 positive, tau-negative inclusions, although other pathologies have been described more infrequently, namely tau-positive Pick's disease and Alzheimer's pathology.[18] Of all the FTLD syndromes, SD is least likely to run in families and is usually sporadic.[19]

Memory in Dementia: Musical Objects, Musical Concepts, and Semantic Memory[edit]

Melodies are a key aspect of musical objects that are thought to form the contents of semantic memory for music.[17] Melodies are defined as familiar tunes that become associated with musical or extra musical meaning. Using familiar songs, such as Christmas carols, were used to test whether SD patients were able to recognize the tones and melodies of the songs if the patients were just given the words of the song. In the analysis of semantic memory using melodies as stimuli, the contents of semantic memory can include many other aspects aside from recognition of the melody, such as the general information about the music (composer, genre, year of release).[17] Results have shown that musicians who suffer from semantic dementia are able to identify and recognize certain melodic tones.

Further exploring the tests of music and semantic memory, results of a study that centered on the comprehension of emotion in music indicated that Alzheimer’s Disease (AD) patients retained the ability to discern emotions from a song while non-AD degenerative disease patients, such as those with semantic dementia (SD), show impaired comprehension of these emotions.[20] Moreover, several dementia patients, all with varied musical experience and knowledge, all demonstrated an understanding of the fundamental governing rules of western music.[21] Essentially, it was found that superordinate knowledge of music, such as the rules of composition, may be more robust than knowledge of specific music.

Regarding the Neurobiological correlates for this study, it was determined, via lesion studies, that bilateral (but especially the left-side of the brain) fronto-temporoparietal areas are significant in the associative processing of melodies.[17] Based on the data of imaging studies that looked at the localization of processing melodies, it can be inferred that the anatomical location of the processes in consistent with the findings that some SD patients have intact melody recognition.[17] Additionally, the neurobiological basis for musical emotion identification implicated the limbic and paralimbic structures in this process. Overall, the results of these studies suggest that the neurobiological basis of musical semantic memory is bilaterally located in the cerebral hemispheres, likely around the fronto-temporal areas of the brain.[17] Unfortunately, due to the lack of studies studying musical semantic memory, conclusions cannot be more specific.

Treatment and Prevention[edit]

There is currently no known curative treatment for SD. The average duration of illness is 8–10 years, and its progression cannot be slowed.[14] Progression of SD can lead to behavioral and social difficulties, thus supportive care is essential for improving quality of life in SD patients as they grow more incomprehensible.

Continuous practice in lexical learning has been shown to improve semantic memory in SD patients.[22]

SD has no known preventative measures.

See also[edit]

References[edit]

  1. ^ Gorno-Tempini, M.L.; Hillis, A.E.; Weintraub, S.; et al. (March 2011). "Classification of primary progressive aphasia and its variants". Neurology. 76 (11): 1006–14. doi:10.1212/WNL.0b013e31821103e6. PMC 3059138. PMID 21325651.
  2. ^ a b c d e f g Bonner, M.F.; Ash, S.; Grossman, M. (November 2010). "The new classification of primary progressive aphasia into semantic, logopenic, or nonfluent/agrammatic variants". Curr Neurol Neurosci Rep. 10 (6): 484–90. doi:10.1007/s11910-010-0140-4. PMC 2963791. PMID 20809401.
  3. ^ Harciarek, M.; Kertesz, A. (September 2011). "Primary progressive aphasias and their contribution to the contemporary knowledge about the brain-language relationship". Neuropsychol Rev. 21 (3): 271–87. doi:10.1007/s11065-011-9175-9. PMC 3158975. PMID 21809067.
  4. ^ Weder ND, Aziz R, Wilkins K, Tampi RR (2007). "Frontotemporal dementias: a review". Ann Gen Psychiatry. 6: 15. doi:10.1186/1744-859X-6-15. PMC 1906781. PMID 17565679.
  5. ^ Warrington, E.K. (November 1975). "The selective impairment of semantic memory". Q J Exp Psychol. 27 (4): 635–57. doi:10.1080/14640747508400525. PMID 1197619.
  6. ^ Snowden, J.S.; Goulding, P.J.; Neary, D. (1989). "Semantic dementia: a form of circumscribed cerebral atrophy". Behav Neurol. 2: 167–82.
  7. ^ a b Hodges, J.R.; Patterson, K.; Oxbury, S.; Funnell, E. (December 1992). "Semantic dementia. Progressive fluent aphasia with temporal lobe atrophy". Brain. 115 (Pt 6): 1783–806. doi:10.1093/brain/115.6.1783. PMID 1486461.
  8. ^ Wilson, Stephen M.; DeMarco, Andrew T.; Henry, Maya L.; Gesierich, Benno; Babiak, Miranda; Mandelli, Maria Luisa; Miller, Bruce L.; Gorno-Tempini, Maria Luisa (May 2014). "What role does the anterior temporal lobe play in sentence-level processing? Neural correlates of syntactic processing in semantic PPA". Journal of Cognitive Neuroscience. 26 (5): 970–985. doi:10.1162/jocn_a_00550. ISSN 0898-929X. PMC 4006153. PMID 24345172.
  9. ^ Cousins, Katheryn AQ; York, Collin; Bauer, Laura; Grossman, Murray (April 2016). "Cognitive and anatomic double dissociation in the representation of concrete and abstract words in semantic variant and behavioral variant frontotemporal degeneration". Neuropsychologia. 84: 244–251. doi:10.1016/j.neuropsychologia.2016.02.025. ISSN 0028-3932. PMC 4808428. PMID 26944874.
  10. ^ Hardy, Chris J. D.; Agustus, Jennifer L.; Marshall, Charles R.; Clark, Camilla N.; Russell, Lucy L.; Bond, Rebecca L.; Brotherhood, Emilie V.; Thomas, David L.; Crutch, Sebastian J. (2017-07-27). "Behavioural and neuroanatomical correlates of auditory speech analysis in primary progressive aphasias". Alzheimer's Research & Therapy. 9 (1): 53. doi:10.1186/s13195-017-0278-2. ISSN 1758-9193. PMC 5531024. PMID 28750682.
  11. ^ Chan, D.; Fox, N.C.; Scahill, R.I.; et al. (April 2001). "Patterns of temporal lobe atrophy in semantic dementia and Alzheimer's disease". Annals of Neurology. 49 (4): 433–42. CiteSeerX 10.1.1.569.8292. doi:10.1002/ana.92. PMID 11310620.
  12. ^ Schroeter, M.L.; Raczka, K.K.; Neumann, J.; von Cramon, D.Y. (2007). "Towards a nosology for frontotemporal lobar degenerations – A meta-analysis involving 267 subjects". NeuroImage. 36 (3): 497–510. doi:10.1016/j.neuroimage.2007.03.024. PMID 17478101.
  13. ^ a b c Iaccarino, Leonardo; Crespi, Chiara; Della Rosa, Pasquale Anthony; Catricalà, Eleonora; Guidi, Lucia; Marcone, Alessandra; Tagliavini, Fabrizio; Magnani, Giuseppe; Cappa, Stefano F. (2015-03-10). "The Semantic Variant of Primary Progressive Aphasia: Clinical and Neuroimaging Evidence in Single Subjects". PLoS ONE. 10 (3): e0120197. doi:10.1371/journal.pone.0120197. ISSN 1932-6203. PMC 4354903. PMID 25756991.
  14. ^ a b c "Semantic variant Primary Progressive Aphasia". Association for Frontotemporal Degeneration. Retrieved 2017-12-18.
  15. ^ Warrington, E.K.; McKenna, P.; Orpwood, L. (April 1998). "Single word comprehension: a concrete and abstract word synonym test". Neuropsychological Rehabilitation. 8 (2): 143–54. doi:10.1080/713755564.
  16. ^ Marcotte, Karine; Graham, Naida L.; Fraser, Kathleen C.; Meltzer, Jed A.; Tang-Wai, David F.; Chow, Tiffany W.; Freedman, Morris; Leonard, Carol; Black, Sandra E. (2017-03-02). "White Matter Disruption and Connected Speech in Non-Fluent and Semantic Variants of Primary Progressive Aphasia". Dementia and Geriatric Cognitive Disorders EXTRA. 7 (1): 52–73. doi:10.1159/000456710. ISSN 1664-5464. PMC 5465709. PMID 28611820.
  17. ^ a b c d e f 20
  18. ^ Davies, R.R.; Hodges, J.R.; Kril, J.J.; Patterson, K.; Halliday, G.M.; Xuereb, J.H. (September 2005). "The pathological basis of semantic dementia". Brain. 128 (Pt 9): 1984–95. doi:10.1093/brain/awh582. PMID 16000337.
  19. ^ Goldman, J.S.; Farmer, J.M.; Wood, E.M.; et al. (December 2005). "Comparison of family histories in FTLD subtypes and related tauopathies". Neurology. 65 (11): 1817–9. doi:10.1212/01.wnl.0000187068.92184.63. PMID 16344531.
  20. ^ 21
  21. ^ 22
  22. ^ Henry, Maya; Beeson, Pélagie; Rapcsak, Steven (February 2008). "Treatment for Anomia in Semantic Dementia". Seminars in Speech and Language. 29 (1): 060–070. doi:10.1055/s-2008-1061625. ISSN 0734-0478. PMC 2699352. PMID 18348092.

Reference 20: Rohani Omar, Julia C. Halistone, and Jason D. Warren, "Semantic Memory for Music in Dementia," Music Perception: An Interdisciplinary Journal 29, no. 5 (June 2012):, doi:10.1525/mp.2012.29.5.467.

Reference 21:Lise Gagnon, Isabelle Peretz, and Tamàs Fülöp, "Musical structural determinants of emotional judgments in dementia of the Alzheimer type.," Neuropsychology 23, no. 1 (2009): , doi:10.1037/a0013790.

Reference 22: J. C. Hailstone, R. Omar, and J. D. Warren, "Relatively preserved knowledge of music in semantic dementia," Journal of Neurology, Neurosurgery & Psychiatry 80, no. 7 (2009): , doi:10.1136/jnnp.2008.153130.

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