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Seme may refer to:

  • Seme Border, a settlement in Nigeria on the border with Benin
  • Seme (dagger), a Maasai term for a type of lion hunting knife
  • Seme (martial arts), Japanese martial arts term meaning to attack
  • Seme (semantics), a small unit of meaning identified as one characteristic of a sememe
  • Pixley ka Isaka Seme (1881?-June 1951) a founding member of the African National Congress
  • Semé, a term used in heraldry to describe a field filled with charges
  • Seme, a manga/anime term for a dominant partner in a homosexual relationship