A senolytic (from the words “senescence” and “lytic” – destroying) is among the class of small molecules under basic research to determine if they can selectively induce death of senescent cells. The goal of those working to develop senolytic agents is to delay, prevent, alleviate, or reverse age-related diseases.. The opposite of senolytic is "senostatic" which means to suppress senescence.
Multiple possible senolytic agents are under investigation. Certain anti-cancer agents may in low doses decelerate aging and age-related diseases. Targeting cancer prevention pathways with anti-cancer agents may confer longevity effects by offering protection from metabolic pathologies during aging, independently of effects on cancer. Navitoclax, also known as ABT-263, was originally studied as an anti-cancer drug.
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