Cahoone is the daughter of a Rocky Mountain dynamite salesman and grew up in Littleton, Colorado. She got her musical start on the drums at twelve years old. Her first stage performance came in a suburban Denver bar, where, at the age of 12, she played drums behind a bunch of bluesmen on open mic night. Cahoone attended Columbine High School.
In 2006, Cahoone focused on singing, songwriting, and guitar playing, skills she'd been honing for nearly 15 years on her own. Her first album was Sera Cahoone (2006). The album was praised by indie-rock radio station KEXP along with NPR. Seattle indie newspaper The Stranger called Sera’s debut "…a breathtaking collection of sad and dusky songs that reveal an artist of remarkable depth as well as a truly stunning voice."
2007–08: Sub Pop and Only As The Day Is Long
Sera and her band recorded her second Sub Pop record in February, 2012 at Bear Creek Studios in Woodinville, Washington over a two-week period with Los Angeles producer Thom Monohan. Additional vocals and tracking were done in Los Angeles over several weeks in early March. The new record, Deer Creek Canyon was released September 25, 2012.