Sergey Kara-Murza was graduated with degree in chemistry from Moscow State University in 1961. Between 1966 and 1972 he worked as a Soviet chemical specialist in Cuba.
In 1983 Sergey Kara-Murza defended his doctoral thesis in history of science and technology and in 1988 became a professor.
Sergey Kara-Murza taught in Russia and Spain and authored several publications and academic studies dedicated to history, science and society. His most prominent works: Mind Manipulations published in 2000 was dedicated to establishing and describing the problem of manipulation of public opinion by pro-Western mass media in Russia and Soviet Civilization, a work about history, political and economic organization of USSR. In the late 1990s and early 2000s Sergey Kara-Murza wrote a number of political and philosophical works on Eurocentrism, Globalization and Color revolutions. His articles were frequent in left-wing/nationalist Russian newspapers such as Pravda, Alexander Prokhanov's Zavtra and Soviet Russia.
Sergey Kara-Murza became known for his anti-Globalization, anti-liberal and anti-Westernist views; however, he also rejects traditional Marxist ideology. He has sharply criticized the Russian economic reforms of the 1990s; he is in favor of a more collectivist economy. Having supported president Putin's policies he is opposed to 'color revolutions'. Sergey Kara-Murza's ideological views have been described as Russian "left-wing conservatism".