|Full name||Sergio Alejandro Santana Piedra|
|Date of birth||August 10, 1979|
|Place of birth||Rio Grande, Zacatecas, Mexico|
|Height||1.80 m (5 ft 11 in)|
|2013–2014||→ Chiapas (loan)||13||(6)|
|2014||→ Querétaro (loan)||22||(12)|
|* Senior club appearances and goals counted for the domestic league only.
Santana first match in the Primera División de México was with C.F. Pachuca on 7 May 2000, against Toluca. He played with C.F. Pachuca for almost five years, from 2000–2005. He was transferred to Chivas de Guadalajara for the Clausura 2006 Tournament at the end of 2005. Sergio was a versatile player for Chivas, playing as a forward, striker, center attacking midfielder, and even as a defensive midfielder on occasions.
Santana represented the Mexico national team in a game against China on 16 April 2008, making his seventh appearance since Ricardo LaVolpe called him for El Tri. Santana stated his desire to leave Chivas following the arrival of Carlos Ochoa, and several months later, it was announced that he would go to Deportivo Toluca F.C.. In Santana's first match for Toluca, he scored a goal against Monarcas Morelia. The match ended in a draw at a goal each.
On June 17, 2009, during the Mexican Football draft in Cancun, the Monterrey announced that Santana was to join their squad. With Monterrey, he won a couple of championships and a Concacaf Champions League in 2010.
Santana's last Mexican club was Club Atlas. He had a poor performance, as did the entire squad, in the Clausura 2012.
On 24 August 2016, Santana played his last game against Club América in a group stage match of the 2016 Copa MX Apertura. He was the captain and was replace at the 44th minute. He finished up his career with a total of 451 matches and having played with nine clubs.
|1.||October 6, 2004||Estadio Hidalgo, Pachuca, Mexico||Saint Vincent and the Grenadines||7–0||7–0||2006 FIFA World Cup qualification – CONCACAF Third Round|
|2.||November 13, 2004||Miami Orange Bowl, Miami, United States||Saint Kitts and Nevis||5–0||5–0||2006 FIFA World Cup qualification – CONCACAF Third Round|
|3.||November 13, 2004||Miami Orange Bowl, Miami, United States||Saint Kitts and Nevis||5–0||5–0||2006 FIFA World Cup qualification – CONCACAF Third Round|
|4.||November 17, 2004||Estadio Tecnológico, Monterey, Mexico||Saint Kitts and Nevis||8–0||8–0||2006 FIFA World Cup qualification – CONCACAF Third Round|
|5.||March 11, 2009||Dick's Sporting Goods Park, Commerce City, Colorado, United States||Bolivia||5–1||5–1||Friendly|
As of 11 March 2009
- Primera División de México: Apertura 2009, Apertura 2010
- CONCACAF Champions League: 2010–11
- InterLiga: 2010