Born in Bucharest, Romania in a Jewish family, he began violin studies at the age of five, was hired as a violinist by the Romanian State Ensemble while still in his teens, making his conducting debut at the age of 17. In his twenties he was named principal conductor of the Romanian National Opera, which he led from 1955 to 1959.
He fled the Communist regime in 1959 and emigrated to Israel. In 1960 he founded the Ramat Gan Chamber Orchestra, which he led until 1967. He also directed the Haifa Symphony from 1959 until 1966. He made his American debut with the Philadelphia Orchestra in 1965 and emigrated to the United States in 1968. Later he was also music director of the Gothenburg Symphony Orchestra, Sweden, from 1966 to 1977, and became chief conductor of the Netherlands Radio Philharmonic in Hilversum, Netherlands, in 1982. Comissiona also held music directorships with some of North America's leading ensembles, including the Baltimore Symphony Orchestra, the Houston Symphony, the Vancouver Symphony Orchestra and was also music director of the New York City Opera. Beginning in 1969 he spent 15 years with the Baltimore Orchestra and transformed it from a little-known ensemble into a nationally respected orchestra, eventually taking it on its first international tour and directing it in its first recordings. He was also the Music Director of the Asian Youth Orchestra. Comissiona was principal conductor of the Spanish national broadcasting network orchestra in Madrid, the RTVE Symphony Orchestra, from 1990 to 1998.
From 1997 until his death, Comissiona served as the conductor of the University of Southern California Thornton School of Music Symphony 
World premiere and other notable performances
He premiered and made the first recordings of a number of modern works including symphonies by Allan Pettersson, who dedicated his Symphony No. 9 to him, as well as works by Michael Jeffrey Shapiro and Elie Siegmeister. Comissiona conducted Siegmeister's An Entertainment for Violin, Piano, and Orchestra at the Merriwether Post Pavilion on July 2, 1976 with Ann Saslav, piano, and Isidor Saslav, the BSO's concertmaster, as soloists. The Saslavs had commissioned the work from Siegmeister.
Comissiona and his wife became American citizens on July 4, 1976, at a special Bicentennial ceremony at Fort McHenry on Baltimore Harbor. He was a longtime resident of New York City. He died of a heart attack in Oklahoma City, Oklahoma just hours before he was to perform.
Honours and awards
He was made a Knight of l'Ordre des Arts et des Lettres of France; received a Mus D. honoris causa from the New England Conservatory in Boston, Massachusetts; was an honorary member of the Royal Swedish Academy of Music and founder national competition for young American conductors of the Baltimore Symphony Orchestra.
- Sergiu Comissiona at AllMusic
- Sergiu Comissiona at Find a Grave
- Interview with Sergiu Comissiona, December 29, 1995
- site conductorsguild 2008