The 1948–49 Serie C was the eleventh edition of Serie C, the third highest league in the Italian football league system, the first one to be organized by the Lega Nazionale.
- ^ 1 point deducted.
- ^ Prato promoted to Serie B 1949-50 after two tie-breakers with Carrarese: Prato-Carrarese 3-3, 1-0.
- ^ Retired after 12 matches for financial problems.
- ^ After winning a tie-breaker with Catania for promotion to Serie B 1949-50 (1-0), Avellino was found guilty of sport illicit, demoted to the last place and relegated.