Serine—pyruvate transaminase

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serine-pyruvate transaminase
Serine-pyruvate transaminase dimer, Human
EC number2.6.1.51
CAS number9030-88-0
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a serine-pyruvate transaminase (EC is an enzyme that catalyzes the chemical reaction

L-serine + pyruvate 3-hydroxypyruvate + L-alanine

Thus, the two substrates of this enzyme are L-serine and pyruvate, whereas its two products are 3-hydroxypyruvate and L-alanine.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-serine:pyruvate aminotransferase. Other names in common use include SPT, and hydroxypyruvate:L-alanine transaminase. This enzyme participates in glycine, serine and threonine metabolism. It employs one cofactor, pyridoxal phosphate.

Structural studies[edit]

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1J04.


  • Cheung GP, Rosenblum IY, Sallach HJ (1968). "Comparative studies of enzymes related to serine metabolism in higher plants". Plant Physiol. 43 (11): 1813&ndash, 20. doi:10.1104/pp.43.11.1813. PMC 1087083. PMID 5699148.
  • Kretovich, V. L.; K. M. Stepanovich (1961). Синтез серина из оксипировнногратной кислоты в растениях [The synthesis of serine from hydroxypyruvate in plants]. Doklady Akademii Nauk SSSR (in Russian). 139: 488&ndash, 490.
  • Sallach HJ (1956). "Formation of serine from hydroxypyruvate and L-alanine". J. Biol. Chem. 223: 1101&ndash, 1108.