Sermorelin

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Sermorelin
Systematic (IUPAC) name
L-Tyrosyl-L-alanyl-L-α-aspartyl-L-alanyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-asparaginyl-L-seryl-L-tyrosyl-L-arginyl-L-lysyl-L-valyl-L-leucylglycyl-L-glutaminyl-L-leucyl-L-seryl-L-alanyl-L-arginyl-L-lysyl-L-leucyl-L-leucyl-L-glutaminyl-L-α-aspartyl-L-isoleucyl-L-methionyl-L-seryl-L-argininamide
Clinical data
Trade names Geref
AHFS/Drugs.com Micromedex Detailed Consumer Information
Pregnancy
category
  • US: C (Risk not ruled out)
Routes of
administration
Injection
Legal status
Legal status
  • US: Discontinued
Identifiers
CAS Number 86168-78-7 YesY
ATC code H01AC04 (WHO) V04CD03 (WHO)
PubChem CID 16132413
DrugBank DB00010 N
ChemSpider 17289071 N
UNII 89243S03TE N
KEGG D08509 YesY
ChEMBL CHEMBL1201490 N
Synonyms GRF 1–29
Chemical data
Formula C149H246N44O42S
Molar mass 3357.882 g/mol
 NYesY (what is this?)  (verify)

Sermorelin (INN) (trade name is Geref), also known as GHRH (1-29), is a growth hormone-releasing hormone (GHRH) analogue used as a diagnostic agent. It is a 29-amino acid polypeptide representing the 1–29 fragment from endogenous human GHRH, and is thought to be the shortest fully functional fragment of GHRH.[1] It is used as a diagnostic agent to assess growth hormone (GH) secretion.[2]

See also[edit]

References[edit]

  1. ^ Prakash A, Goa KL (August 1999). "Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency". BioDrugs. 12 (2): 139–57. doi:10.2165/00063030-199912020-00007. PMID 18031173. 
  2. ^ Pharmacology (Rang, Dale, Ritter & Moore, ISBN 0-443-07145-4, 5th ed., Churchill Livingstone 2003).