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Serotonergic (/ˌsɛrɵtɵˈnɜrɨk/, /ˌsɪr-/) or serotoninergic (/ˌsɛrɵˌtnɨˈnɜrɨk/, /ˌsɪr-/) means "pertaining to or affecting serotonin". Serotonin is a neurotransmitter. A synapse is serotonergic if it uses serotonin as its neurotransmitter. A serotonergic neuron produces serotonin. A substance is serotonergic if it produces its effects via interactions with the serotonin system, such as by stimulating or blocking neurotransmission.

A serotonergic or serotonergic agent is any chemical that modifies the effects of serotonin in the body. Some different types of serotonergics drugs include the following:

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