The Serranía del Perijá, Cordillera de Perijá or Sierra de Perijá is a mountain range, an extension of the eastern Andean branch (Cordillera Oriental), in northern South America, between Colombia and Venezuela, ending further north in the Guajira Desert, a total distance of about 310 km. It separates the Maracaibo Basin from the Cesar River valley. Some of the area has been considered as a Flora and Fauna Sancturary.
Starting at the southernmost point, near Ocaña, Colombia, this mountain range forms the boundary between the Colombian departments of Norte de Santander and Cesar, and then as the range progresses north, it forms the international boundary between Venezuela (Zulia State) and Colombia (Cesar Department). Included in the range are the Sierra Motilones, Sierra Valledupar, and Sierra Oca. The highest point is Cerro de Las Tetas at 3630 meters, followed by Cerro Irapa at 3540 m., Serranía de Macuira at 864 m., and Cerro Aceite at 853 m.
The range is 58% in Venezuela, and 42% in Colombia. Venezuela has set aside a substantial part of the central part of the range as a national park (Sierra de Perijá National Park), and Colombia has a smaller one. In the Venezuelan portion there are Amerindian reservations for the Yucpa and Barí people, and in Colombia for the Iroko and Sokorpa people. Venezuela has started a colonialization border plan building new communities along the border in the Perijá. The town of Cojoro was the first one completed, followed by communities for the Wayuu and Goajira peoples.