Serum-derived bovine immunoglobulin/protein isolate

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search

Serum-derived bovine immunoglobulin/protein isolate (SBI) is a medical food product derived from bovine serum obtained from adult cows in the United States.

Mechanism of Action[edit]

Unlike common dietary proteins, SBI contains a concentrated source of immunoglobulin that may aid in the management of chronic diarrhea or loose and frequent stools. Immunoglobulins found in SBI have been shown to bind to microbial components with immune-activating potential from a variety of bacteria, fungi and viruses, including those implicated in human disease.[1] The putative mechanism of action features, this binding of inflammatory antigens may prevent their passage into the lamina propria of the bowel wall, presumably due steric exclusion.[2] The resultant dampening of immune response in the gut-associated lymphoid tissue (GALT) is believed to allow for restoration of intestinal homeostasis, leading to resumption of normal gut function and nutrient absorption.[3]

The therapeutic effect of SBI’s action on various GI conditions with chronic diarrhea provides a specific nutritional benefit that cannot be provided by normal dietary proteins alone or by increased intake of foods which contain immunoglobulin (i.e., milk).[4]

Medical uses[edit]

In humans, oral immunoglobulins may improve function in the gastrointestinal (GI) tract.[4] Conditions like HIV-enteropathy, IBS-D (irritable bowel syndrome with diarrhea) , SIBO (small intestine bacterial overgrowth), recurrent C. difficile infection-associated diarrhea and post-infectious IBS-D often limit or impair the body's ability to absorb and digest select nutrients including water.[3] Clinical studies have indicated that serum-derived bovine immunoglobulin/protein isolate may help to reduce diarrhea and to restore the ability of the GI tract to properly absorb and utilize those nutrients.[5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]


Research into bovine- and porcine-associated sources of immunoglobulin began in the field of animal health.[21][22] Studies examined the health effects of adding immunoglobulins to the feed of  early-weaned piglets that had developed intestinal inflammation, intestinal barrier dysfunction, and general malnutrition causing the piglets not to thrive.[23] These issues often manifested in diarrhea, dehydration, and death for young piglets. The addition of immunoglobulin-rich protein isolates  to the piglets’ food improved digestion, metabolism, and feed intake, increasing lean muscle mass and protein utilization.[24][25] Gastric infection and diarrhea were also reduced in the post-weaning phase.


  1. ^ Horgan, A (April 26–30, 2014). "Serum-derived bovine immunoglobulin/protein isolate binds to pathogen associated molecular patterns". FASEB J. 28 (Suppl 1): 836.6. doi:10.1096/fasebj.28.1_supplement.836.6 (inactive 2018-10-04).
  2. ^ Detzel, CJ (April 2015). "Bovine immunoglobulin/protein isolate binds pro-inflammatory bacterial compounds and prevents immune activation in an intestinal co-culture model". PLOS One. 10 (4): e0120278. doi:10.1371/journal.pone.0120278. PMC 4382133. PMID 25830826.
  3. ^ a b Petschow, Bryon W. (May 2014). "Serum-derived bovine immunoglobulin/protein isolate: postulated mechanism of action for management of enteropathy". Clinical and Experimental Gastroenterology. 7: 181–90. doi:10.2147/CEG.S62823. PMC 4041178. PMID 24904221.
  4. ^ a b Petschow, Bryon W (January 2015). "Dietary Requirement for Serum-Derived Bovine Immunoglobulins in the Clinical Management of Patients with Enteropathy". Digestive Diseases and Sciences.
  5. ^ Wilson, Dale. "Evaluation of Serum-Derived Bovine Immunoglobulin Protein Isolate in Subjects with Diarrhea-Predominant Irritable Bowel Syndrome". Clinical Medicine Insights: Gastroenterology. 6: 49–60.
  6. ^ Arrouk, R (2017). "Serum-derived bovine immunoglobulin (SBI) for children with diarrhea predominant irritable bowel syndrome (d-IBS)". Naspghan.
  7. ^ Rana, A (2017 Apr). "Tolerability, and efficacy of serum-derived bovine immunoglobulin in children with diarrhea-predominant irritable bowel syndrome". Gastroenterology. 152 (5): S652. doi:10.1016/S0016-5085(17)32299-0. Check date values in: |date= (help)
  8. ^ Crawford, C (2015). "Post-infectious irritable bowel syndrome with functional diarrhea following C. difficile infections: Case studies of responses using serum-derived bovine immunoglobulin". Gastro and Hepatology Res. 4 (4): 1577–81.
  9. ^ Good, L (2017). "SBI Retrospective Study Group. Oral serum bovine immunoglobulin improves IBS-D symptoms analyzed from patient medical charts" (PDF). Biol Med Case Rep. 1 (1): 16–23.
  10. ^ Shaw, AL (2017). "Impact of serum-derived bovine immunoglobulin/protein isolate therapy on irritable bowel syndrome and inflammatory bowel disease: A survey of patient perspective". Patient Prefer Adherence. 11 (1001): 1–7. doi:10.2147/PPA.S134792. PMC 5460652. PMID 28615929.
  11. ^ Valentin, N (2017). "A. Potential mechanisms of effects of serum-derived bovine immunoglobulin/protein isolate therapy in patients with diarrhea-predominant irritable bowel syndrome". Physiol Rep. 5 (5): e13170. PMC 5350178. PMID 28275113.
  12. ^ Weinstock, LB (2014). "Serum-derived bovine immunoglobulin/protein isolate therapy for patients with refractory irritable bowel syndrome" (PDF). Open Journal of Gastroenterology. 4: 329–334.
  13. ^ Beaurele, BD (2015). "Successful management of refractory ulcerative colitis with orally administered serum-derived bovine immunoglobulin therapy" (PDF). Clin Case Rep Rev. 1 (4): 90–92.
  14. ^ Shafran, I (2015). "Management of inflammatory bowel disease patients with oral serum-derived bovine immunoglobulin". Thera Adv Gastroenterol. 8 (6): 1–9. doi:10.1177/1756283X15593693. PMC 4622288. PMID 26557889.
  15. ^ Soriano, RA (2017). "Clinical and pathologic remission of pediatric ulcerative colitis with serum-derived bovine immunoglobulin added to standard treatment regimen". Case Rep Gastroenterol. 11 (2): 335–343. doi:10.1159/000475923. PMC 5471788. PMID 28626380.
  16. ^ Ferm, S (2017). "Serum-derived bovine immunoglobulin as novel adjunct in complicated Clostridium difficile colitis treatmen". ACG Case Rep J. 4: e64. PMC 5425282. PMID 28516109.
  17. ^ Gelfand, MS (2017). "Oral serum-derived bovine immunoglobulin for management of infectious diarrhea due to norovirus and cryptosporidiosis in solid organ transplant patients". Infect Dis Clin Practice. 25 (4): 218–220.
  18. ^ Arikapudi, S (2017). "Serum bovine immunoglobulin for chemotherapy-induced gastrointestinal mucositis". Amer J Hospice and Palliative Med.
  19. ^ Iduru S, Burnett BP.  Management of celiac disease and non-celiac gluten sensitivity with serum-derived bovine immunoglobulin/protein isolate. Poster presented (#1343) at 2015 ACG Annual Scientific Meeting, Honolulu, HI.  October 19, 2015.
  20. ^ Kumar V, Zhou E, Yuliya A, Mansoor MS, Sharma P, Feuerstadt P. Serum-derived bovine immunoglobulin (SBI) is safe and well tolerated in patients with recurrent C. difficile infection (RCDI) treated medically. Poster (P100) Presented at American College of Gastroenterology Annual Meeting, Orlando, FL. October 15, 2017.
  21. ^ Pierce, JL (December 2005). "Effects of spray-dried animal plasma and immunoglobulins on performance of early weaned pigs". Journal of Animal Science. 83 (12): 2876–85. doi:10.2527/2005.83122876x. PMID 16282627.
  22. ^ Peace, Ralph Michael (July 2011). "Spray-Dried Porcine Plasma Influences Intestinal Barrier Function, Inflammation, and Diarrhea in Weaned Pigs". Journal of Nutrition. 141 (7).
  23. ^ van Beers-Schreurs, Hetty M.G (June 1998). "Weaning and the Weanling Diet Influence the Villous Height and Crypt Depth in the Small Intestine of Pigs and Alter the Concentrations of Short-Chain Fatty Acids in the Large Intestine and Blood". Journal of Nutrition. 128 (6).
  24. ^ Torralladorna, David (2010). "Spray Dried Animal Plasma as an Alternative to Antibiotics in Weanling Pigs - A Review". Asian-Australasian Journal of Animal Sciences. 23 (1).
  25. ^ Kuchibhatla, R (2015). "Nutritional impact of dietary plasma proteins in animals undergoing experimental challenge and implications for patients with inflammatory bowel disorders. A meta-analysis". Adv. Nutr. 6 (5): 541–51. doi:10.3945/an.114.007930. PMC 4561828. PMID 26374176.