Serum-derived bovine immunoglobulin/protein isolate
Serum-derived bovine immunoglobulin/protein isolate (SBI) is a medical food product derived from bovine serum obtained from adult cows in the United States.
Mechanism of Action
Unlike common dietary proteins, SBI contains a concentrated source of immunoglobulin that may aid in the management of chronic diarrhea or loose and frequent stools. Immunoglobulins found in SBI have been shown to bind to microbial components with immune-activating potential from a variety of bacteria, fungi and viruses, including those implicated in human disease. The putative mechanism of action features, this binding of inflammatory antigens may prevent their passage into the lamina propria of the bowel wall, presumably due steric exclusion. The resultant dampening of immune response in the gut-associated lymphoid tissue (GALT) is believed to allow for restoration of intestinal homeostasis, leading to resumption of normal gut function and nutrient absorption.
The therapeutic effect of SBI’s action on various GI conditions with chronic diarrhea provides a specific nutritional benefit that cannot be provided by normal dietary proteins alone or by increased intake of foods which contain immunoglobulin (i.e., milk).
In humans, oral immunoglobulins may improve function in the gastrointestinal (GI) tract. Conditions like HIV-enteropathy, IBS-D (irritable bowel syndrome with diarrhea) , SIBO (small intestine bacterial overgrowth), recurrent C. difficile infection-associated diarrhea and post-infectious IBS-D often limit or impair the body's ability to absorb and digest select nutrients including water. Clinical studies have indicated that serum-derived bovine immunoglobulin/protein isolate may help to reduce diarrhea and to restore the ability of the GI tract to properly absorb and utilize those nutrients.
Research into bovine- and porcine-associated sources of immunoglobulin began in the field of animal health. Studies examined the health effects of adding immunoglobulins to the feed of early-weaned piglets that had developed intestinal inflammation, intestinal barrier dysfunction, and general malnutrition causing the piglets not to thrive. These issues often manifested in diarrhea, dehydration, and death for young piglets. The addition of immunoglobulin-rich protein isolates to the piglets’ food improved digestion, metabolism, and feed intake, increasing lean muscle mass and protein utilization. Gastric infection and diarrhea were also reduced in the post-weaning phase.
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- Crawford, C (2015). "Post-infectious irritable bowel syndrome with functional diarrhea following C. difficile infections: Case studies of responses using serum-derived bovine immunoglobulin". Gastro and Hepatology Res. 4 (4): 1577–81.
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- Shaw, AL (2017). "Impact of serum-derived bovine immunoglobulin/protein isolate therapy on irritable bowel syndrome and inflammatory bowel disease: A survey of patient perspective". Patient Prefer Adherence. 11 (1001): 1–7. doi:10.2147/PPA.S134792. PMC 5460652. PMID 28615929.
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- Soriano, RA (2017). "Clinical and pathologic remission of pediatric ulcerative colitis with serum-derived bovine immunoglobulin added to standard treatment regimen". Case Rep Gastroenterol. 11 (2): 335–343. doi:10.1159/000475923. PMC 5471788. PMID 28626380.
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- Kumar V, Zhou E, Yuliya A, Mansoor MS, Sharma P, Feuerstadt P. Serum-derived bovine immunoglobulin (SBI) is safe and well tolerated in patients with recurrent C. difficile infection (RCDI) treated medically. Poster (P100) Presented at American College of Gastroenterology Annual Meeting, Orlando, FL. October 15, 2017.
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