Serum-separating tube

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Serum-separating tubes, also known as serum separator tubes or SSTs, are used in medical clinical chemistry tests requiring blood serum.

A large SST II vacutainer

SSTs are sometimes called "marble-top tubes", "tiger-tops", or "gold-topped tubes", referring to the stoppers which are either gold, red with a gold ring on top, or marbled red and grey. Marble-top tubes are also referred to as "tiger-tops" in some clinics. SPS tubes have a paler colour, sometimes leading confusion; these are known as "yellow tops" not "gold". Trademarked versions include Covidien "Corvac" tubes.

They contain a special gel that separates blood cells from serum, as well as particles to cause blood to clot quickly. The blood sample may then be centrifuged, allowing the clear serum to be removed for testing.[1]

These tubes should be used with care when measuring drug or hormone levels because the drug or hormone may diffuse from the serum into the gel, causing a reduction in measured level. The gel in SST II tubes (which appears slightly less opaque) is supposed[weasel words] to have less effect on drug levels in serum.[citation needed]


  1. ^ Blood sampling in sheep Archived 2007-02-03 at the Wayback Machine (170kb pdf) from Purdue University, 2003.