Setiptiline

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Setiptiline
Setiptiline 2D structure.svg
Clinical data
AHFS/Drugs.com International Drug Names
Routes of
administration
Oral
ATC code
  • none
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ECHA InfoCard 100.055.123
Chemical and physical data
Formula C19H19N
Molar mass 261.36 g/mol
3D model (Jmol)
 NYesY (what is this?)  (verify)

Setiptiline (Tecipul), also known as teciptiline, is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). It was launched in 1989 for the treatment of depression in Japan by Mochida.[1][2]

Chemistry[edit]

Setiptiline has a tetracyclic structure and is a close analogue of mianserin and mirtazapine, with setiptiline being delta(13b,4a),4a-carba-mianserin, and mirtazapine being 6-aza-mianserin.

Pharmacology[edit]

Setiptiline acts as a norepinephrine reuptake inhibitor,[3] α2-adrenergic receptor antagonist,[4] and serotonin receptor antagonist,[5] likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine.[3]

See also[edit]

References[edit]

  1. ^ Buschmann, H.; Torrens, A.; Vela, J. M. (2007). Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application. 1. Wiley VCH. p. 248. ISBN 978-3-527-31058-6. 
  2. ^ Swiss Pharmaceutical Society, ed. (2000). Index Nominum 2000: International Drug Directory. Medpharm Scientific Publishers. p. 942. ISBN 3-88763-075-0. 
  3. ^ a b Niho, T.; Ito, C.; Shibutani, Y.; Hashizume, H.; Yamaguchi, K. (1986). "Pharmacological Properties of MO-8282, a Novel Antidepressant". Nihon yakurigaku zasshi. Folia Pharmacologica Japonica. 88 (4): 309–320. doi:10.1254/fpj.88.309. PMID 3792961. 
  4. ^ Mizota, M.; Oikawa, Y.; Nakayama, K.; Mizuguchi, K.; Takarada, T.; Kojima, M.; Kanehiro, H.; Funato, H.; Kayamoto, M.; Sato, M.; Niho, T. (1986). "Pharmacological Studies of MO-8282, a New Antidepressant". Nihon yakurigaku zasshi. Folia Pharmacologica Japonica. 88 (6): 457–466. doi:10.1254/fpj.88.457. PMID 2881854. 
  5. ^ Przegaliński, E.; Baran, L.; Siwanowicz, J.; Rawłów, A. (1986). "The Lack of Antidepressant Properties and a Potent Central Antiserotonin Activity of Org 8282". Polish Journal of Pharmacology and Pharmacy. 38 (4): 377–384. PMID 3774630.