Sharpless oxyamination

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The Sharpless oxyamination (often known as Sharpless aminohydroxylation) is the chemical reaction of alkenes with alkyl imido osmium compounds to form vicinal amino-alcohols.[1][2][3] A comprehensive review of this reaction was authored by McLeod et al. in 2002.[4]

The Sharpless oxyamination

Vicinal amino-alcohols are important products in organic synthesis and recurring pharmacophores in drug discovery.[5]


  1. ^ Sharpless, K. B.; Patrick, D. W.; Truesdale, L. K.; Biller, S. A. J. Am. Chem. Soc. 1975, 97, 2305. (doi:10.1021/ja00841a071)
  2. ^ Herranz, E.; Biller, S. A.; Sharpless, K. B. J. Am. Chem. Soc. 1978, 100, 3596-3598. (doi:10.1021/ja00479a051)
  3. ^ Herranz, E.; Sharpless, K. B. Org. Synth., Coll. Vol. 7, p.375 (1990); Vol. 61, p.85 (1983). (Article)
  4. ^ Bodkin, J. A.; McLeod, M. D. J. Chem. Soc., Perkin Trans. 1, 2002, 2733–2746. (doi:10.1039/b111276g)
  5. ^ Bäckvall, J. E.; Oshima, K.; Palermo, R. E.; Sharpless, K. B. J. Org. Chem. 1979, 44, 1953. (doi:10.1021/jo01326a013)