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Manandhar was born in 1960 in Nepal's capital of Kathmandu. She is a postgraduate in MS. Her first novel was Shaili, published in 1985. although by then she had published Nami in 1982, a collection of short stories; and other literary publications. On 15 January 2003 Manandhar was awarded the prestigious Ganki-Basundhara Award by the Ganki-Basundhara Award Academy.