According to its lyricist, Richey Edwards, the song's title refers to "Desire. In other bibles and holy books, no truth is possible until you empty yourself of desire. All commitment otherwise is fake/lies/economic convenience". Nicky Wire also noted, "It's quite a simple song, both musically and lyrically. It's kind of like the Buddhist thing where you can only reach eternal peace by shedding every desire in your body."
A promo video for the song was directed by Alfonso Doring, which featured performance clips interspersed with shots of art mannequins. In the music magazine Melody Maker, Wire described the music video to "She Is Suffering" as "absolute shite beyond belief". It was released on the band's Forever Delayed video compilation DVD (2002).