Sheshatshiu (Innu pronunciation: [ʃehatʃju]) is an Innu Federal Reserve in the Canadian province of Newfoundland and Labrador, located approximately 30 kilometres north of Goose Bay. (Some references may spell the community's name as Sheshatshit — the t spelling is more traditional in the Innu-aimun language, but the u is used more commonly in English to avoid inappropriate connotations. The name means "a narrow place in the river".)
In November 2000, the community, along with Davis Inlet, took the unprecedented step of asking the Canadian federal government to step in and assist with a local addiction crisis. Due to a variety of factors, including economic adversity, alcoholism and gas sniffing were both rampant in the community, in some cases affecting children as young as five years old.