Shlomo Hestrin (Hebrew שלמה הסטרין ; born 1914; died 2 February 1962) was an Israeli biochemist.
Hestrin was born in 1914 in Winnipeg, Manitoba. He emigrated with his parents to then British Mandate of Palestine, now Israel, in 1932.
In 1957, Hestrin was awarded the Israel Prize, in exact sciences, jointly with his research partner David Sidney Feingold and their student Gad Avigad.
Hestrin's sister, Sara Hestrin-Lerner, was the recipient of the Israel Prize, in medical science, in 1955.