Sicilian refers to the autonomous Italian island of Sicily.
Sicilian can also refer to:
- Sicilian language, a Romance language spoken on the island of Sicily, its satellite islands, and southern Calabria
- Sicilians, people from or with origins in Sicily
- Sicilian Defence, a chess opening
- The Sicilian, a 1984 novel by Mario Puzo
- The Sicilian (film), a 1987 action film based on the novel