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Sien may refer to:

  • Sien of Diauehi, king of an ancient people of north-east Anatolia
  • Sien, Germany, an Ortsgemeinde – a municipality belonging to a Verbandsgemeinde, a kind of collective municipality – in the Birkenfeld district in Rhineland-Palatinate, Germany
  • Sien Hoornik, mistress of Vincent van Gogh and model for his famous drawing Sorrow
  • Wong Foon Sien (1899–1971), Canadian journalist and labour activist
  • Osowa Sień
  • Ot en Sien, a 1902 old children's book, written by a teacher in Drenthe, the Netherlands
  • Red Sien, a 1975 Dutch comedy film directed by Frans Weisz, produced by Rob du Mée
  • Sien Sovv
  • Sien Eggers
  • Sien Devliegher