Sigal Avin was born in Miami, Florida, and moved to Israel with her parents at the age of ten. When she was sixteen her parents moved back to the States, this time to California. Her father got an offer to manage the Mondrian Hotel in Los Angeles. Avin decided to stay in Israel and finish school.   
She wrote and directed her first play How to make a boy in 1999 for Haifa’s International children’s theatre festival. 
In 2000 she wrote and directed Shmulik is a new friend for the same festival and won several prizes, among them, best show and best director. The story was about 3 kids who kidnap a grandmother with a banana because they don’t have one.  
Her first play for adults, With a gun and a smile, a sad comedy about small people with small dreams, was chosen by the Israeli culture department to participate in the Australian International Playwrights Festival.  
In 2002 Avin created a show called Freaks, inspired by the Todd Brownings film of the same name. The show had no words, was highly praised and was invited to festivals all over the world.     
In 2005 Avin created and was show-runner of Telenovela Inc, which told her personal story about the struggle she had trying to write her first telenovela, and the hectic, surreal, life around that industry. The shows still air on Israeli TV in syndication.  
Between 2005-2007 Avin was Artistic Manager and director of the young Habima Company (Israel’s national theatre), where she created Taxi, a play about lonely souls and the Israeli decadent night life and directed Marivoux’s The Dispute as a modern reality TV show.  
In 2007 Avin created the dramedy Mythological Ex for the Israeli channel 2 Keshet. CBS bought the format and the American version entitled The Ex List premiered in 2008 starring Elizabeth Reaser as the lead.     
In 2010 Avin wrote and directed a short film called You shall know no grief, in the 48 hour film project, and won first prize. 
In 2013, Avin, inspired by the fact she had become a mother, co-created, wrote and directed the comedy series Bilti Hafich (Irreversible), about what happens to a couple after having their first child. The show starring Adi Ashkenazi and Muli Shulman, premiered on channel 2 Reshet and was the number one comedy in Israel that year. 
In February 2016 the second season of Bilti Hafich, that Avin wrote and directed, aired in Israel. 
In December 2016, Avin launched a project she created, wrote and directed called Zematrid on Facebook in Israel. The project includes five short films that show the dynamic behind sexual harassment. The project went viral in a couple of hours. Among the actors in the films are Lior Ashkenazi and Hadas Yaron.      
In April 2017 Avin launched the American version of her films depicting sexual harassment called #that's harassment. David Schwimmer and Mazdack Rassi from MILK studios produced. The films star - David Schwimmer, Cynthia Nixon, Emmy Rossum, Bobby Cannavale, Michael Kelly, and more.    
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- Stern, Itay (March 24, 2016). "A conversation with the most successful script woman in Israel". Haaretz.
- Yudovich, Daphna (June 6, 2006). "An Intreview with Sigal Avin". Globes.
- Class of 1998. Studio Alumni. Yoram Lowenstein acting studio site.
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- With a gun and a smile. Studio show archive. Yoram Lowenstein acting studio site.
- "Freaks". Habima Theatre site.
- "Freaks". Studio show archive. Yoram Lowenstein acting studio site.
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- Crystal, Meirav (May 13, 2008). "CBS greenlights Israeli-based series ‘Mythological X’".. Ynet.
- Schneider, Michael (September 12, 2008). "Diane Ruggiero quits 'Ex List'. Variety.
- (June 18, 2008). "America finds its ex list on israeli tv". israel21c.
- Canaf, Uria (July 19. 2010). "48 hour film festival". ynet.
- Averbuch, Li-Or (May 5, 2013). "Bilti Hafich of Reshet had an average of 27.8% this season". Globes.
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- Saval, Malina (October 10, 2014). "Variety’s 10 TV Scribes to Watch". variety.
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- 'zematrid' official site.
- Makin, Shira (December 12, 2016). 'Zematrid' - short films that expose the dynamic behind sexual harassment'. Haaretz.
- Eliyahu, Dorin (December 26, 2016). "About 'Zematrid'". mako.
- Guy Pines show (December 27, 2016). "'zematrid' - Sigal Avin's project about sexual harassment". Nana 10.
- Stadtmauer, Lori (December 27, 2016). "This is what sexual harassment looks like". Ynet.
- Ben Noon, Sagi (December 26, 2016). "In the parliameny, in the army, in the theater and at work: short movies that remind us that sexual harassment is everywhere". Walla!.
- (12 April 2017). That's harassment. David Schwimmer and Sigal Avin tackle sexual harassment – video. Guardian
- Truong, Peggy (April 3, 2017). David Schwimmer Launches New Campaign to Fight Sexual Harassment. Cosmopolitan
- Winfrey, Graham (April 3, 2017). Schwimmer Short ‘The Boss’ Kicks Off Campaign to Fight Sexual Harassment — Watch. Indie Wire
- Stern, Carly (April 3, 2017). David Schwimmer calls out President Trump's 'really disturbing boast' about 'committing sexual assault' as he debuts his own short film series aimed at combating sexual harassment. Daily Mail
- Moshe Benjamin (June 6. 2015). "Profile of Amit Mashiah". Ice.
- Bien-Lubobich, Anat (July 7, 2016). "Israel advertising companies 2016". Globes.
- Toker, Nati (November 22, 2016). "In three years 20% of Mccann Tel Aviv employees will be Haredi, Arabs or Beta Israel". The Marker.