Sign of Hertoghe

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The Sign of Hertoghe or Queen Anne's sign is a thinning or loss of the outer third of the eyebrows, and is a sign of hypothyroidism or dermatitis atopica. The sign is named after Eugene Hertoghe of Antwerp, a pioneer in thyroid function research.[1][2]

Queen Anne's sign[edit]

Anne of Denmark mourning the death of her son Henry in 1612

The association with Anne of Denmark is based on portraiture, although history does not suggest that she suffered an underactive thyroid.[3] The eponym is disputed by some, though it has been suggested that Anne of France, Anne of Brittany, Anne of Austria, Anne Boleyn and Anne of Cleves may all be eliminated as candidates.[4]


  1. ^ Schatz, Henry A. (May 1922). "The Role of the Thyroid Gland in Otolaryngology". The Pennsylvania Medical Journal 25 (8): 529. 
  2. ^ "Complimentary Dinner given by Dr. William Seaman Bainbridge". American Medicine 9 (4): 308. April 1914. Retrieved 2014-12-12. 
  3. ^ Lane Furdell E (May 2007). "Eponymous, anonymous: Queen Anne's sign and the misnaming of a symptom". J Med Biogr 15 (2): 97–101. PMID 17551609. 
  4. ^ Keynes M (February 2009). "Letter to the editor". J Med Biogr 17 (1): 62. doi:10.1258/jmb.2007.007021. PMID 19190203.