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Signer may refer to :
- Martin Signer (b. 1977 in Zug) is a well-known Swiss economist.
- Roman Signer (b. 1938 in Appenzell) is principally a visual artist who works in sculpture, photography, and video.
- Rudolf Signer (1903-1990) contributed to the discovery of the DNA double helix.
- Walter Signer (October 12, 1910 - July 23, 1974) was a Major League Baseball pitcher who played for the Chicago Cubs in 1943 and 1945.
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